DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP11A1 and Cyp12b2

DIOPT Version :9

Sequence 1:	NP_000772.2	Gene:	CYP11A1 / 1583	HGNCID:	2590	Length:	521	Species:	Homo sapiens
Sequence 2:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	139/496 - (28%)
Similarity:	225/496 - (45%)	Gaps:	66/496 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    46 RPFNEIPSPGDNGWLNLYHFWRETG----THKVHLHHVQNFQKYGPIY--REKLGNVESVYVIDP 104
            |.|.|||.|   ..|.:..|:...|    |:.:.::.:.. :.||.||  ...:|...:|:..:|
  Fly    51 RSFGEIPGP---SLLRMLSFFMPGGALRNTNLIQMNRLMR-EMYGDIYCIPGMMGKPNAVFTYNP 111

Human   105 EDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI------GVLLKKSAAWKKDRVALNQEVMAPEA 163
            :|..:.:::||..|.|..:.. :.|::...||.      |:...:...|...|..:|..:|..:.
  Fly   112 DDFEMTYRNEGVWPIRIGLES-LNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQN 175

Human   164 TKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNP 228
            .:..||.||.:|::|:..|..: :...:...:.|..:.|..:|||||:.|....|.|:|.:..:|
  Fly   176 VRQNLPQLDQISKEFIDKLETQ-RNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDP 239

Human   229 EAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGS 293
            .|.|....:...|:.|. ..::.|.::..::|..:|..:..:|.|   .|| |.| |.|...:|.
  Fly   240 NADRLAKHMRDFFNYSF-QFDVQPSIWTFYKTAGFKKFLKTYDNI---TDI-TSN-YIETAMRGF 298

Human   294 VHHD---YRGILYRLLGDSKMSFEDIKANVT---EMLAGGVDTTSMTLQWHLYEMARNLKVQDML 352
            ..:|   .:.:|.:||..:|      |..||   :||..|:||||......||.:|||...|:.|
  Fly   299 GKNDDGKTKCVLEQLLEHNK------KVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQEKL 357

Human   353 RAE---VLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTL 414
            |.|   :|.....:..|..|  :.:|.|:|.|||.||:..|:....|....||||..|.:|..|.
  Fly   358 RRELLRILPTTKDSLTDQNT--KNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTG 420

Human   415 VQVAIYALGREPTFFFDPENFDPTRWLSKD-----------KNITYFRNLGFGWGVRQCLGRRIA 468
            |.:.:..|..:..:|.....|.|.|||..|           :....|..|.||:|.|.|:|:|||
  Fly   421 VLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIA 485

Human   469 ELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISF 509
            |||:...|:.:|.:::|.              .:||.||.:
  Fly   486 ELEIETLLVRLLRSYKVS--------------WLPETPIEY 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP11A1	NP_000772.2	p450	52..511	CDD:278495	135/490 (28%)
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	133/485 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820