Protein Alignment CYP11A1 and Cyp12b2

DIOPT Version :10

• Sequence 1: NP_000772.2
• Gene: CYP11A1 / 1583
• HGNCID: 2590
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 496
• Identity: 139/496 - (28%)
• Similarity: 225/496 - (45%)
• Gaps: 66/496 - (13%)

Human    46 RPFNEIPSPGDNGWLNLYHFWRETG----THKVHLHHVQNFQKYGPIY--REKLGNVESVYVIDP 104
            |.|.|||.|   ..|.:..|:...|    |:.:.::.:.. :.||.||  ...:|...:|:..:|
  Fly    51 RSFGEIPGP---SLLRMLSFFMPGGALRNTNLIQMNRLMR-EMYGDIYCIPGMMGKPNAVFTYNP 111

Human   105 EDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI------GVLLKKSAAWKKDRVALNQEVMAPEA 163
            :|..:.:::||..|.|..:.. :.|::...||.      |:...:...|...|..:|..:|..:.
  Fly   112 DDFEMTYRNEGVWPIRIGLES-LNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQN 175

Human   164 TKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNP 228
            .:..||.||.:|::|:..|..: :...:...:.|..:.|..:|||||:.|....|.|:|.:..:|
  Fly   176 VRQNLPQLDQISKEFIDKLETQ-RNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDP 239

Human   229 EAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGS 293
            .|.|....:...|:.|. ..::.|.::..::|..:|..:..:|.|   .|| |.| |.|...:|.
  Fly   240 NADRLAKHMRDFFNYSF-QFDVQPSIWTFYKTAGFKKFLKTYDNI---TDI-TSN-YIETAMRGF 298

Human   294 VHHD---YRGILYRLLGDSKMSFEDIKANVT---EMLAGGVDTTSMTLQWHLYEMARNLKVQDML 352
            ..:|   .:.:|.:||..:|      |..||   :||..|:||||......||.:|||...|:.|
  Fly   299 GKNDDGKTKCVLEQLLEHNK------KVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQEKL 357

Human   353 RAE---VLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTL 414
            |.|   :|.....:..|..|  :.:|.|:|.|||.||:..|:....|....||||..|.:|..|.
  Fly   358 RRELLRILPTTKDSLTDQNT--KNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTG 420

Human   415 VQVAIYALGREPTFFFDPENFDPTRWLSKD-----------KNITYFRNLGFGWGVRQCLGRRIA 468
            |.:.:..|..:..:|.....|.|.|||..|           :....|..|.||:|.|.|:|:|||
  Fly   421 VLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIA 485

Human   469 ELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISF 509
            |||:...|:.:|.:::|.              .:||.||.:
  Fly   486 ELEIETLLVRLLRSYKVS--------------WLPETPIEY 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP11A1	NP_000772.2	CYP11A1	82..508	CDD:410736	128/453 (28%)
Cyp12b2	NP_611370.2	CYP24A1-like	87..525	CDD:410677	129/457 (28%)