DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP11A1 and Cyp12d1-d

DIOPT Version :9

Sequence 1:	NP_000772.2	Gene:	CYP11A1 / 1583	HGNCID:	2590	Length:	521	Species:	Homo sapiens
Sequence 2:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	130/515 - (25%)
Similarity:	227/515 - (44%)	Gaps:	81/515 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    42 TRSPRPFNEIPSPGDNGWLNLYHFWR------ETGTHKVHLHHVQNFQKYGPIY--REKLGNVES 98
            |...:.::|||.|      |.:.|.|      |.....:..:.....::||.||  ....|..:.
  Fly    36 TEEHKTYDEIPRP------NKFKFMRAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDW 94

Human    99 VYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRP------IGVLLKKSAAWKKDRVALNQE 157
            |...:.:|:.::|::||..|.|..:.. :.|.:.:.||      .|::..::.||.|.|.|:|..
  Fly    95 VTTFNTKDIEMVFRNEGIWPRRDGLDS-IVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPI 158

Human   158 VMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGML 222
            .|.|...:.:...|..::.:|:..: :.|:...:.....|.:|::.|..|||:..|.|..:.|::
  Fly   159 FMQPRGLRMYYEPLSNINNEFIERI-KEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLI 222

Human   223 EEVVNPEAQRFIDAIYQMFHTSVPM------LNLPPDLFRLFRTKTWK-------DHVAAWDVIF 274
            .:  |.:..   ||: .:|.||..:      |::.|.::::..|.|::       |.:.....:.
  Fly   223 RK--NRDNS---DAL-TLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVSQKML 281

Human   275 SKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVT-----EMLAGGVDTTSMT 334
            .:    .|:...:.||.|...:. ..:|.||:        :|...|.     ::|..|||.|:..
  Fly   282 KE----NQDALEKRRQAGEKINS-NSMLERLM--------EIDPKVAVIMSLDILFAGVDATATL 333

Human   335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQL--------VPLLKASIKETLRLHPIS 391
            |...|..::::...|..||.|:|:.       |.|...|        :|.|:|.||||||.:|..
  Fly   334 LSAVLLCLSKHPDKQAKLREELLSI-------MPTKDSLLNEENMKDMPYLRAVIKETLRYYPNG 391

Human   392 VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWL-----SKDKNITYFR 451
            ....|...||::|..|.:|..|.|.:....|.:|.|::..|:.|.|.|||     .|...::.|.
  Fly   392 FGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFT 456

Human   452 NLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTF 511
            .|.||:|.|.|:|:|:.:|||...:..::.||.||...  |....|..:.:.|..|:|.|
  Fly   457 FLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNR--DASRPFKTMFLMEPAITFPF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP11A1	NP_000772.2	p450	52..511	CDD:278495	126/503 (25%)
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	117/467 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820