DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RASEF and rasef

DIOPT Version :9

Sequence 1:	NP_689786.2	Gene:	RASEF / 158158	HGNCID:	26464	Length:	740	Species:	Homo sapiens
Sequence 2:	XP_699335.4	Gene:	rasef / 570731	ZFINID:	ZDB-GENE-081105-157	Length:	706	Species:	Danio rerio

Alignment Length:	758	Identity:	388/758 - (51%)
Similarity:	518/758 - (68%)	Gaps:	75/758 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     5 GDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFAR 69
            |...::.|||.:|.|||.:.|||:|:.||..:|:||.|:.::.:::|.|||.|.||.|..:||..
Zfish     2 GSEAQMQRLRELFHACDVDHSGRIEKWEFEKICSELHVQSSEIDSLFSRLDTDEDGTINLEEFME 66

Human    70 GFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCGPASPGRAWQDFQAR 134
            ||                         .|:|..:|.|...:.|...:::        ||:||::|
Zfish    67 GF-------------------------QESHLLKEPEMSGEPAGETSSA--------AWEDFKSR 98

Human   135 LGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAA 199
            |||:.|||||.:||:||||||.|.|||::..||.|:.:||:|||:.:||||:||:|||||||:.:
Zfish    99 LGDQFKFIPRIDQVATLYQNIRLTEPRMVPQYERVLVSFIKEIRILNTEMEHLALAVKRAQDQMS 163

Human   200 MQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVS 264
            |||||:|||||.||..||..||..|.:|||..||.::.||::::.:||..|:.|:.:|.|::.||
Zfish   164 MQLSEMEEEMDHRIHTAERNTRLQESKKAEATLSSMKHQYDSQICELQQKIQTLQMMENQNRSVS 228

Human   265 QKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYT 329
            .||:.:|||:|..:|.::|||:|::|||:.||:||||||||:||||..|||:|.|||..:::.::
Zfish   229 LKEETSALKRQNNELMLQNQKLKQELLESHTNVAFLQSELDSLKSDLTDQSINCERDEALMKCFS 293

Human   330 EDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSP 394
            |:|::||||||:||.||||||||||.||:|||:|.|| :::..::.:|||  :..::.|.:.||
Zfish   294 EERDNLERQIEMLQVANRKLHDSNDSLRTALESSQSK-SKTQRVSGLSPG--VYVNTRKNVCHS- 354

Human   395 QPLGYDRSSRSSYVDED--------------CDS--LALCDPLQRTNCEVDSLPESCFDSGLSTL 443
               .:||...:...:||              |||  ||||||::|.:||.||||    |||:|||
Zfish   355 ---YFDRCCNTCVDEEDYDQFRLMAGMRRQSCDSLALALCDPMRRRSCEEDSLP----DSGMSTL 412

Human   444 RDPNEYDSEVEYKHQRGFQ--RSHGVQESFGGDASDTDVPDIRDEETFGLEDVASVLDWKPQGSV 506
            |....||    |:|:|...  .:.....:..||.|||:|.::|:|...| .|..||..|.|...|
Zfish   413 RSNIGYD----YEHERTSSPVEAEDSNTTVSGDTSDTEVVEMREEAASG-SDSESVQSWMPSKPV 472

Human   507 SEGSIVSSSRKPISALSPQTDLVDDNAKSFS-SQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENI 570
            ....:.:|.:|.:||:..:.: .|:.|.|.| |:|||:|||||||||||||||:|||||||:.|.
Zfish   473 QTDDVSASGKKCLSAIFTERE-QDELAVSQSPSEKAYRIVLAGDAAVGKSSFLLRLCKNEFKGNT 536

Human   571 SATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREW 635
            |||||||||||||:|||..|||||||||||||||||||||||:||||||||||||||||||:|||
Zfish   537 SATLGVDFQMKTLVVDGVPTVLQLWDTAGQERFRSIAKSYFRRADGVLLLYDVTCEKSFLNVREW 601

Human   636 VDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEA 700
            ||:|||.:.:.:||||||||.|:|..|..:|..|:|..:||||||||.||||||||||||||:||
Zfish   602 VDIIEDVSQDDIPIMLVGNKTDLRKEALQDGVTCIPTSYGEKLAMTYSALFCETSAKDGSNIIEA 666

Human   701 VLHLAREVKKRTDK-DDSRSITNLTGTNSKK--SPQMKNCCNG 740
            ||||||||.|..|. .:..|:..|:|.::||  ||   |||.|
Zfish   667 VLHLAREVTKHADDYKEPVSVAKLSGNHTKKMSSP---NCCMG 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RASEF	NP_689786.2	EFh	12..71	CDD:238008	27/58 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..110		4/27 (15%)
		SMC_N	<174..>351	CDD:330553	99/176 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..403		8/26 (31%)
		Rab	542..706	CDD:206640	131/163 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..740		11/29 (38%)
rasef	XP_699335.4	EFh	9..69	CDD:238008	29/84 (35%)
		EF-hand_7	10..68	CDD:290234	26/57 (46%)
		DUF904	201..>253	CDD:283624	21/51 (41%)
		RAB	508..674	CDD:197555	133/165 (81%)
		Rab	508..672	CDD:206640	131/163 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327556
Domainoid	1	1.000	361	1.000	Domainoid score	I5592
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H28424
Inparanoid	1	1.050	700	1.000	Inparanoid score	I4279
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46600
OrthoDB	1	1.010	-	-		D1184845at2759
OrthoFinder	1	1.000	-	-		FOG0011158
OrthoInspector	1	1.000	-	-		oto46092
orthoMCL	1	0.900	-	-		OOG6_109730
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8127
SonicParanoid	1	1.000	-	-		X5099
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.200