Protein Alignment CYP7A1 and Cyp28d2

DIOPT Version :9

• Sequence 1: NP_000771.2
• Gene: CYP7A1 / 1581
• HGNCID: 2651
• Length: 504
• Species: Homo sapiens
• Sequence 2: NP_608911.1
• Gene: Cyp28d2 / 33748
• FlyBaseID: FBgn0031688
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 477
• Identity: 103/477 - (21%)
• Similarity: 187/477 - (39%)
• Gaps: 154/477 - (32%)

Human    66 VFTCK------LMGKYVH--FITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTT 122
            |||.:      :..:|:|  :.|:..|:|.       .:|:.         |.::..|.:.|
  Fly    76 VFTTRVPQLLVMCPEYIHKIYATDFRSFHN-------NEWRN---------FVNKKTDMILG--- 121

Human   123 ENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAW--------------------- 166
               |:.|:.|         .:...|....|| |.:|.|...|.:
  Fly   122 ---NNPFVLT---------GDEWKERRSEIM-PALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMA 173

Human   167 VTEGM----YSFCY--RVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGL-- 223
            .:||:    .|.||  .|:.:.| |.:..:..|...|....::..:.| ..|:.:|.::|..|
  Fly   174 TSEGLDAMDLSLCYTTEVVSDCG-LGVSAQSFTDTPTPLLKMIKRVFN-TSFEFIFYSVVTNLWQ 236

Human   224 --------P----------IHMFRTAHNAREKLAESLRHE------NLQKRESI---SELISLRM 261
                    |          :.:.|.....|.:..|..|.:      .||:::.:   :.||:...
  Fly   237 KVRKFYSVPFFNKETEVFFLDIIRRCITLRLEKPEQQRDDFLNYMLQLQEKKGLHTDNILINTMT 301

Human   262 FLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKV 326
            |:   |..|:.......|::::                 :.||||..    ::|::.:.:|.
  Fly   302 FI---LDGFETTALVLAHIMLM-----------------LGRNPEEQ----DKVRKEIGSAD--- 339

Human   327 SLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIR---------TAKEDFTLHLEDGSYNIR 382
                    |:..::::||.||:.|.|:|||.|..:..|         ..|...|:||:.|
  Fly   340 --------LTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPFEFANKNGRTVHLKPG----- 391

Human   383 KDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGR 447
              |::.:..:.:|.||:.|.||||||.:|:|:.||....::...|:     |:.||.|...|||.
  Fly   392 --DVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGV-----YLAFGDGPRHCPGM 449

Human   448 LFAIHEIKQFLILMLSYFELEL 469
            .||:.::|..|:.:|..||:::
  Fly   450 RFALTQLKAALVEILRNFEIKV 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP7A1	NP_000771.2	p450	32..497	CDD:365848	103/477 (22%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	103/477 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5364
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860