Protein Alignment LINGO2 and Fili

DIOPT Version :10

• Sequence 1: NP_689783.1
• Gene: LINGO2 / 158038
• HGNCID: 21207
• Length: 606
• Species: Homo sapiens
• Sequence 2: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 399
• Identity: 126/399 - (31%)
• Similarity: 191/399 - (47%)
• Gaps: 41/399 - (10%)

Human    15 LAVVLIFMGSTIGCPARCEC--SAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEF 77
            |.:|::...:|..||::|:|  ...|....|....|..:|..:..|||.::|:.||::::   ||
  Fly    29 LTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTL---EF 90

Human    78 ISYPL---LEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISEN 139
             |.|.   ||.:|||.|||..:....|.....||:|.|..|.:..:....|.||:||..||:|.|
  Fly    91 -SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFN 154

Human   140 KIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLI 204
            :|..:......||.:|..|::.:|::|.:....|.|:.:||.|......|..||...|.||.:|.
  Fly   155 RIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALK 219

Human   205 SLHLKHLNI-------------------------NNMPVYAFKRLFHLKHLEIDYWPLLDMMPAN 244
            ||.:. ||:                         :.:.:.||:.|..||||::.. ..|.|:|..
  Fly   220 SLDMS-LNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSD-NNLTMVPTQ 282

Human   245 SLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLS-YNPISTIEAGMFSDLIRLQELHI-VG 306
            .|..| |||.|::.....|.:|.:||.:|.:|..|:|| .:.:..|::..|.|...||.||: ..
  Fly   283 QLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNN 347

Human   307 AQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQP 371
            .||..|....|||...:..:.:..|.|:||....|...: |:.|.:.:|||.|:|.||| |.|..
  Fly   348 PQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQ-LQKLYLGDNPLQCNCSLLW-LWRLV 410

Human   372 TLQFGGQQP 380
            |..|.|..|
  Fly   411 TGNFEGVDP 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LINGO2	NP_689783.1	LRRNT	27..60	CDD:214470	9/34 (26%)
		leucine-rich repeat	39..57	CDD:275380	3/17 (18%)
		LRR	48..>340	CDD:443914	100/322 (31%)
		LRR 1	58..79		8/20 (40%)
		leucine-rich repeat	59..82	CDD:275380	8/22 (36%)
		LRR 2	82..103		9/23 (39%)
		leucine-rich repeat	83..106	CDD:275380	9/22 (41%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR 5	154..175		5/20 (25%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		LRR 6	178..199		7/20 (35%)
		leucine-rich repeat	179..202	CDD:275380	9/22 (41%)
		LRR 7	202..223		7/45 (16%)
		leucine-rich repeat	203..250	CDD:275380	17/72 (24%)
		LRR 8	226..247		7/20 (35%)
		LRR 9	250..271		8/20 (40%)
		leucine-rich repeat	251..274	CDD:275380	8/22 (36%)
		LRR 10	274..295		6/21 (29%)
		leucine-rich repeat	275..298	CDD:275380	7/23 (30%)
		LRR 11	298..319		8/21 (38%)
		leucine-rich repeat	299..322	CDD:275380	10/23 (43%)
		LRR 12	322..343		5/20 (25%)
		leucine-rich repeat	323..343	CDD:275380	5/19 (26%)
		LRRCT	355..408	CDD:214507	14/26 (54%)
		Ig	411..500	CDD:472250
		Ig strand B	428..432	CDD:409353
		Ig strand C	441..445	CDD:409353
		Ig strand E	466..470	CDD:409353
		Ig strand F	480..485	CDD:409353
		Ig strand G	493..496	CDD:409353
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	88/282 (31%)
		leucine-rich repeat	75..97	CDD:275378	9/25 (36%)
		leucine-rich repeat	98..121	CDD:275380	9/22 (41%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		leucine-rich repeat	218..265	CDD:275380	8/47 (17%)
		leucine-rich repeat	266..289	CDD:275380	9/23 (39%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	7/23 (30%)
		LRR_8	337..397	CDD:404697	18/60 (30%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)