Protein Alignment CYP4B1 and Cyp6a22

DIOPT Version :10

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 465
• Identity: 112/465 - (24%)
• Similarity: 202/465 - (43%)
• Gaps: 86/465 - (18%)

Human    88 FIGFLNIYEP----------------DYA----KAVY--SRGDPKAPDVYDFFLQWIGRGLLVLE 130
            |.||..:..|                |:|    :.:|  .|.||            :...|..::
  Fly    70 FAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDP------------LTGHLFRID 122

Human   131 GPKWLQHRKLLTPGFHYDVLK---PYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHM----A 188
            ||||...|:.::|.|....:|   |.|....|....:..:..:.|..|     ..::|.:    .
  Fly   123 GPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCG-----ILEIGDLMARYT 182

Human   189 LNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYH----NDFIYWLTPHGRRFLR 249
            .:.:.:|.||....||   |:.....|:      |.:|..|.:.|    :.||... |...||||
  Fly   183 SDVIGRCAFGVECNGL---RNPEAEFAI------MGRRAFSERRHCKLVDGFIESF-PEVARFLR 237

Human   250 ACQVAHDHTD---QVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVD 311
            ..|:..|.||   .::||.....:::.:.:.       ||:::|:..:...::.:.  ::.|:..
  Fly   238 MRQIHQDITDFYVGIVRETVKQREEQGIVRS-------DFMNLLIEMKQRGELTIE--EMAAQAF 293

Human   312 TFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL----GDQDFFQWDDLGKMTYLTMCIK 372
            .|...|.||:.|.:.:.||.:|..|..|.:.|||:.:.|    |:   |.:|.:.::.|:.:.|.
  Fly   294 IFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGE---FTYDSMQELRYMELVIA 355

Human   373 ESFRLYPPVPQVYRQLSKPVTFVDGRS---LPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTE 434
            |:.|.||.:||:.| :|:.:....|..   :..|.::.:.:|.:|.:.|::|:|..|...||..:
  Fly   356 ETLRKYPILPQLTR-ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLAD 419

Human   435 NASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDP---SRLPIKMPQLVLRSK 496
            ..::|...|::||..|||||||.:|...:..:.....|..|.||:.|   .::......::|...
  Fly   420 QLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPA 484

Human   497 NGFHLHLKPL 506
            ||.:|.::.|
  Fly   485 NGIYLKVQQL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	110/459 (24%)
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	110/457 (24%)