Protein Alignment CYP4B1 and Cyp6a17

DIOPT Version :10

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_652018.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 536
• Identity: 128/536 - (23%)
• Similarity: 225/536 - (41%)
• Gaps: 89/536 - (16%)

Human    20 LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFG---------HALEIQETGSLDKVVSWAH 75
            |.|::..|.|:....||:.........|....|.|||         |..||..    |....:.:
  Fly     4 LALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFR----DYYFKYKN 64

Human    76 -QFPYAHPLWFGQFIGFLN---IYEPDYAKAVY--------SRG-------DPKAPDVYDFFLQW 121
             .:|:|     |.|..|..   :.:.:..|.|.        :||       ||
  Fly    65 SDYPFA-----GFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDP------------ 112

Human   122 IGRGLLVLEGPKWLQHRKLLTPGFHYDVLK---PYVA-VFTESTRIMLDKWEEKAREGKSFDIFC 182
            :...|..:||.||...|..|||.|....:|   |.|. |..|..::...|  ..|..|:..::..
  Fly   113 LSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSK--TAADRGQVLEVVD 175

Human   183 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN--DFIYWLTPHGR 245
            .|.....:.:..|.||        ...:|.|...::...:.::.:...:|.|  |...:..|...
  Fly   176 LVARYTADVIGNCAFG--------LNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLS 232

Human   246 RFLRA---CQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILL-------GARDEDDIK 300
            |.||.   .|.|.|...:::||    ..|.::|.|   .:..||:|.|:       ....||.:.
  Fly   233 RRLRLKLNIQEAEDFYTKIVRE----TIDYRLRTK---EKRNDFMDSLIEMYKNEQSGNSEDGLT 290

Human   301 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD-FFQWDDLGKM 364
            .:  :|.|:...|...|.:|:::.:.:.||.:|...:.|.:.|||:..:.|..: .|.::.:.:|
  Fly   291 FN--ELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEM 353

Human   365 TYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA-GSLISMHIYALHRNSAVWPDPEVFDS 428
            .||...:.|:.|.||.:..:.|......:..|.:...| |:::.:....:|.:..::|:||:|..
  Fly   354 KYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKP 418

Human   429 LRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDP-SRLPIK--MPQ 490
            .||:.|..:.|....::||..|||||||.:|.|.:..|..|..:..::||:.| :::|:|  :..
  Fly   419 ERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKN 483

Human   491 LVLRSKNGFHLHLKPL 506
            :::.::||.||.::.|
  Fly   484 ILISAENGIHLKVEKL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	112/474 (24%)
Cyp6a17	NP_652018.1	CYP6-like	66..493	CDD:410679	110/462 (24%)