DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4B1 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	170/556 - (30%)
Similarity:	269/556 - (48%)	Gaps:	99/556 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    15 LWASGLILVLGFLKL-IHL-------LLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGS--LDK 69
            :|    |::..||.| :.|       ||||:   :.::||.||....|.|:|.::..|.:  |::
  Fly     1 MW----IVLCAFLALPLFLVTYFELGLLRRK---RMLNKFQGPSMLPLVGNAHQMGNTPTEILNR 58

Human    70 VVSWAHQ-----FPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGD-PKAPDVYDFFLQWIGRGLLV 128
            ...|.|:     |.|    |.|.:...: :..|.|.:.:.|... ....||||....|:|.|||.
  Fly    59 FFGWWHEYGKDNFRY----WIGYYSNIM-VTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLT 118

Human   129 LEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLM 193
            ..|.||.:|||::||.||:::|:.:..|..|::...:|:.::.|..|..||...:..::.|:.:
  Fly   119 STGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVI- 182

Human   194 KCTFGRGDTGLG------HSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQ 252
             |     ||.:|      .:|.||...|..|:|..::.|..|....|.:::...|....:.:..:
  Fly   183 -C-----DTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLK 241

Human   253 VAHDHTDQVIRE----RKAALQ-----DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRA 308
            ...|.|:::|.:    ||:.|:     ||..|||      :.|||.||.:: .|...|:..:|..
  Fly   242 TLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKK------MAFLDTLLSSK-VDGRPLTSQELYE 299

Human   309 EVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG------DQDFFQWDDLGKMTYL 367
            ||.|||||||||||||:.:.:|.::.:|:.|.:...|..:::|      |..|   .::..|.:|
  Fly   300 EVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATF---QEISTMKHL 361

Human   368 TMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFS 432
            .:.|||:.||||.||.:.|...|... :||..:|.|:.:::.:..|..|..|:.||..|...||.
  Fly   362 DLFIKEAQRLYPSVPFIGRFTEKDYV-IDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFD 425

Human   433 TENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE------------------FSL 479
            .|   |..||.::||||||||||||:||:.|:|.|.:..:..||                  ..|
  Fly   426 RE---KPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGL 487

Human   480 DPSRL-----------PIKMPQLVLRSKNGFHLHLK 504
            .|:..           ||....:.|:|:||.||.:|
  Fly   488 QPAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	155/511 (30%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	147/460 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154804
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650