Protein Alignment CYP4B1 and Cyp4c3

DIOPT Version :10

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 181/535 - (33%)
• Similarity: 278/535 - (51%)
• Gaps: 50/535 - (9%)

Human     7 SLSFSSLGLWASG----LILVLGFLKLIHLLL---RRQTLAKAMDKFPGPPTHWLFGHALE--IQ 62
            |:..|.:|...||    .:.:||.: ||.|::   ||..|.|.::|.|||......|:|:|  :.
  Fly    13 SILLSKVGQVISGYSPITVFLLGSI-LIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVD 76

Human    63 ETGSLDKVVSWAHQFPYAHPLWFGQFIGF----------LNIYEPDYAKAVYS--RGDPKAPDVY 115
            .....::|:.       ...|| |..||.          :.::||:..:.:.:  :...|:.| |
  Fly    77 HDELFNRVIG-------MQKLW-GTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHD-Y 132

Human   116 DFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180
            |:...|:|.|||.....||...||:|||.||:.:|..::.||.|.:.::..|...:. ..::|::
  Fly   133 DYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEV-GSEAFNL 196

Human   181 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGR 245
            |..|....|:.:.:...||......:| :|.|..||..:..::|.|.......:|||:.||...:
  Fly   197 FPYVTLCTLDIVCETAMGRRIYAQSNS-ESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYK 260

Human   246 RFLRACQVAHDHTDQVIRERKA--ALQDEKVRKKIQN----------RRHLDFLDILLGARDEDD 298
            .........|..::.|||||||  |:..|.......|          ::.|.|||:|:.|..|..
  Fly   261 LHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGT 325

Human   299 IKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGD--QDFFQWDDL 361
            : ||:.|:|.|||||||||||||::.|||.|:.:..:||:|.|..||:..|.||  :......:|
  Fly   326 V-LSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNL 389

Human   362 GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 426
            ..|.||..|||:|.||:|.||.:.|.:.:.|. :.|:.:|||:...:..||||||..|:|.||.|
  Fly   390 MDMRYLECCIKDSLRLFPSVPMMARMVGEDVN-IGGKIVPAGTQAIIMTYALHRNPRVFPKPEQF 453

Human   427 DSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIK-MPQ 490
            :...|..||.:.|||||::||||||||||||:||:.|.|.|.:..|.:::......|..:. :.:
  Fly   454 NPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGE 518

Human   491 LVLRSKNGFHLHLKP 505
            |:||.|:|..:.:.|
  Fly   519 LILRPKDGLRVKITP 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	159/461 (34%)
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	154/437 (35%)