Protein Alignment CYP4B1 and Cyp6a8

DIOPT Version :10

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Alignment Length: 542
• Identity: 126/542 - (23%)
• Similarity: 220/542 - (40%)
• Gaps: 102/542 - (18%)

Human    17 ASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAH 81
            |..|:.:|.:  .||   |:.|..|... .|....|.:.|:..|:|:|.::       |:....|
  Fly    11 AVALLAILTY--YIH---RKLTYFKRRG-IPFVAPHLIRGNMEELQKTKNI-------HEIFQDH 62

Human    82 PLWFGQ----FIGFLNIYEP----------------DYA----KAVY--SRGDPKAPDVYDFFLQ 120
            ...|.:    |:||.....|                |::    |.::  .:.||
  Fly    63 YNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDP----------- 116

Human   121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLK----PYVAVFTESTRIMLDKWEEKAREGKSFDIF 181
             |...|..|:|.:|...|..|:..|....:|    ..|:|..|...:|    .||..:....:|.
  Fly   117 -ISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVM----HEKVPKNSVLEIR 176

Human   182 CDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDL------TLLMQQRLVSFQYHNDFIYWL 240
            ..|....::.:..|.||.....|...:....|.....|      |||           |.|:...
  Fly   177 DLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLL-----------NGFMRSY 230

Human   241 TPHGRR--FLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSD 303
            ....|:  .:|......:...:::.|..|..:.|.:::.       ||:|:|:..:::.::.|.:
  Fly   231 PKLARKLGMVRTAPHIQEFYSRIVTETVAVREKEHIKRN-------DFMDMLIELKNQKEMTLEN 288

Human   304 AD---------LRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD-FFQW 358
            .|         :.|:...|...|.:|::|.:.:.||.:|..|:.|.:.|.||.|::...| .|.:
  Fly   289 GDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTY 353

Human   359 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRS---LPAGSLISMHIYALHRNSAVW 420
            :....:.||...:.|:.|||..||.:.|..:|... |.|..   :.||..:.:...|:|.:.:::
  Fly   354 ECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYV-VPGHPNFVIEAGQSVIIPSSAIHHDPSIY 417

Human   421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSL---DPS 482
            |:|..|...|||.|.::.|...|::||..|||||||.:|...:.::..|:.:..|:||.   .|:
  Fly   418 PEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPN 482

Human   483 RLPIKMPQLVLRSKNGFHLHLK 504
            .|.......||..|:|.:|.::
  Fly   483 PLVYDPKSFVLGVKDGIYLKVE 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	111/488 (23%)
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	108/464 (23%)