Protein Alignment CYP4B1 and Cyp6a8

DIOPT Version :9

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Alignment Length: 542
• Identity: 126/542 - (23%)
• Similarity: 220/542 - (40%)
• Gaps: 102/542 - (18%)

Human    17 ASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAH 81
            |..|:.:|.:  .||   |:.|..|... .|....|.:.|:..|:|:|.::       |:....|
  Fly    11 AVALLAILTY--YIH---RKLTYFKRRG-IPFVAPHLIRGNMEELQKTKNI-------HEIFQDH 62

Human    82 PLWFGQ----FIGFLNIYEP----------------DYA----KAVY--SRGDPKAPDVYDFFLQ 120
            ...|.:    |:||.....|                |::    |.::  .:.||
  Fly    63 YNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDP----------- 116

Human   121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLK----PYVAVFTESTRIMLDKWEEKAREGKSFDIF 181
             |...|..|:|.:|...|..|:..|....:|    ..|:|..|...:|    .||..:....:|.
  Fly   117 -ISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVM----HEKVPKNSVLEIR 176

Human   182 CDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDL------TLLMQQRLVSFQYHNDFIYWL 240
            ..|....::.:..|.||.....|...:....|.....|      |||           |.|:...
  Fly   177 DLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLL-----------NGFMRSY 230

Human   241 TPHGRR--FLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSD 303
            ....|:  .:|......:...:::.|..|..:.|.:::.       ||:|:|:..:::.::.|.:
  Fly   231 PKLARKLGMVRTAPHIQEFYSRIVTETVAVREKEHIKRN-------DFMDMLIELKNQKEMTLEN 288

Human   304 AD---------LRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD-FFQW 358
            .|         :.|:...|...|.:|::|.:.:.||.:|..|:.|.:.|.||.|::...| .|.:
  Fly   289 GDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTY 353

Human   359 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRS---LPAGSLISMHIYALHRNSAVW 420
            :....:.||...:.|:.|||..||.:.|..:|... |.|..   :.||..:.:...|:|.:.:::
  Fly   354 ECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYV-VPGHPNFVIEAGQSVIIPSSAIHHDPSIY 417

Human   421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSL---DPS 482
            |:|..|...|||.|.::.|...|::||..|||||||.:|...:.::..|:.:..|:||.   .|:
  Fly   418 PEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPN 482

Human   483 RLPIKMPQLVLRSKNGFHLHLK 504
            .|.......||..|:|.:|.::
  Fly   483 PLVYDPKSFVLGVKDGIYLKVE 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	117/507 (23%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	117/505 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810