Protein Alignment CYP4B1 and Cyp6a19

DIOPT Version :9

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 542
• Identity: 130/542 - (23%)
• Similarity: 219/542 - (40%)
• Gaps: 111/542 - (20%)

Human    22 LVLGFLKLI-HLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWF 85
            ||:|.|.|: ..:|:..|..|... .|..|.:...|:..|:..|..|..::...:       |.|
  Fly     7 LVVGVLTLVAWWVLQNYTYWKRRG-IPHDPPNIPLGNTGELWRTMPLAGILKRTY-------LKF 63

Human    86 -----GQFIGF-------LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG------------- 125
                 |.|.||       :.|.:.|:.|.|..|...|..|          ||
  Fly    64 RKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHD----------RGVYHNEKDDPLTNN 118

Human   126 LLVLEGPKWLQHRKLLTPGFHYDVLKPYVA----VFTESTRIMLDKWEEKAREGKSFDIFCDVGH 186
            |..:||.||...|:.||..|....:|...:    |..|..|::.:|....::..:..||   |..
  Fly   119 LATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDI---VSR 180

Human   187 MALNTLMKCTFGRGDTGLGHSRDSSYYLAVS-----------DLTLLMQQRL---VSFQYHNDFI 237
            ...:.:..|.||.....|...:.....:..|           ||.:....:|   :.||:
  Fly   181 FTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQF----- 240

Human   238 YWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGAR---DEDDI 299
              |.|..::|.  .::..|..|.            ::::|:...   ||:|.|:..:   |:.|.
  Fly   241 --LLPSVQKFY--MKIVQDTIDY------------RMKRKVTRN---DFMDTLIDMKQQYDKGDK 286

Human   300 K--LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD-FFQWDDL 361
            :  |:..::.|:...|...|.:..::.:.:.||.:|...:.|.:.|.|:..:|...: ..::|.:
  Fly   287 ENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSM 351

Human   362 GKMTYLTMCIKESFRLYPPVPQVYR------QLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 420
            ..:.|:...|.||.|.:|.|..:.|      |.|.|..|::     ||:.:.:....:|.:...:
  Fly   352 QDLFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIE-----AGTGVLVSTLGIHHDPEFY 411

Human   421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLP 485
            |:||.|...||..|...||...||:||.||||||||.:|...::.:..|:.:..|.|.|.| :.|
  Fly   412 PEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHP-KTP 475

Human   486 IKMP----QLVLRSKNGFHLHL 503
            :.|.    .|:|.|:.|.||::
  Fly   476 VPMKYTINNLLLGSEGGIHLNI 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	120/512 (23%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	120/512 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810