Protein Alignment CYP4B1 and Cyp6a19

DIOPT Version :10

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 543
• Identity: 133/543 - (24%)
• Similarity: 223/543 - (41%)
• Gaps: 113/543 - (20%)

Human    22 LVLGFLKLI-HLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWF 85
            ||:|.|.|: ..:|:..|..|... .|..|.:...|:..|:..|..|..::...:       |.|
  Fly     7 LVVGVLTLVAWWVLQNYTYWKRRG-IPHDPPNIPLGNTGELWRTMPLAGILKRTY-------LKF 63

Human    86 -----GQFIGF-------LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG------------- 125
                 |.|.||       :.|.:.|:.|.|..|...|..|          ||
  Fly    64 RKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHD----------RGVYHNEKDDPLTNN 118

Human   126 LLVLEGPKWLQHRKLLTPGFHYDVLKPYVA----VFTESTRIMLDKWEEKAREGKSFDIFCDVGH 186
            |..:||.||...|:.||..|....:|...:    |..|..|::.:|....::..:..||   |..
  Fly   119 LATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDI---VSR 180

Human   187 MALNTLMKCTFGRGDTGL----------GHS--RDSSYYLAVSDLTLLMQQRL---VSFQYHNDF 236
            ...:.:..|.||.....|          |:|  |:..:...| ||.:....:|   :.||:
  Fly   181 FTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLV-DLLIFGMPKLAVKLGFQF---- 240

Human   237 IYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGAR---DEDD 298
               |.|..::|.  .::..|..|.            ::::|:...   ||:|.|:..:   |:.|
  Fly   241 ---LLPSVQKFY--MKIVQDTIDY------------RMKRKVTRN---DFMDTLIDMKQQYDKGD 285

Human   299 IK--LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD-FFQWDD 360
            .:  |:..::.|:...|...|.:..::.:.:.||.:|...:.|.:.|.|:..:|...: ..::|.
  Fly   286 KENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDS 350

Human   361 LGKMTYLTMCIKESFRLYPPVPQVYR------QLSKPVTFVDGRSLPAGSLISMHIYALHRNSAV 419
            :..:.|:...|.||.|.:|.|..:.|      |.|.|..|::     ||:.:.:....:|.:...
  Fly   351 MQDLFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIE-----AGTGVLVSTLGIHHDPEF 410

Human   420 WPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRL 484
            :|:||.|...||..|...||...||:||.||||||||.:|...::.:..|:.:..|.|.|.| :.
  Fly   411 YPEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHP-KT 474

Human   485 PIKMP----QLVLRSKNGFHLHL 503
            |:.|.    .|:|.|:.|.||::
  Fly   475 PVPMKYTINNLLLGSEGGIHLNI 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	119/494 (24%)
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	115/470 (24%)