DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4B1 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	167/539 - (30%)
Similarity:	258/539 - (47%)	Gaps:	76/539 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    20 LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGS--LDKVVSWAHQFPYAH- 81
            :.|.|..|.:.:|.|......:.::||.||....|.|:|.::.:..|  ||.|.||.||:...:
  Fly     7 IFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNF 71

Human    82 PLWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPG 144
            ..|.|.:...| :....|.:.:.|...  .|: |:|.....|:|.|||...|.||.:|||::||.
  Fly    72 VFWIGTYSNVL-VTSSKYLEFILSSQTLITKS-DIYQLTHPWLGLGLLTSTGSKWHKHRKMITPA 134

Human   145 FHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLG---- 205
            ||:::|:.:..|..|::...:...:..|.....||......::.|:.:  |     ||.:|
  Fly   135 FHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI--C-----DTAMGVSIN 192

Human   206 --HSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAA 268
              .:|.||...|..|:...:..|.......|:.:|.|.|....:.|..:...|.|:::|.:|..|
  Fly   193 AMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEA 257

Human   269 LQ---------DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSG 324
            .:         ||..|||      :.|||.||.: ..|...|:..:|..||.|||||||||||||
  Fly   258 HKSGAVSTNAGDEFTRKK------MAFLDTLLSS-TIDGRPLNSKELYEEVSTFMFEGHDTTTSG 315

Human   325 ISWFLYCMALYPEHQHRCREEVREILGDQDF-----FQWDDLGKMTYLTMCIKESFRLYPPVPQV 384
            :|:.:|.::.:.:.|.:..:|.||::|:.:.     ||  ::.:|.||.:.|||:.|:||.||.:
  Fly   316 VSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQ--EISQMKYLDLFIKEAQRVYPSVPFI 378

Human   385 YRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 449
            .|...|... :||..:|.|:.:::.:..|..|..|:.||..|...||..|   |..||.::||||
  Fly   379 GRFTEKDYV-IDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELE---KPGPFEYVPFSA 439

Human   450 GPRNCIGQQFAMSEMKVVTAMCLLRFEF--------------------------SLDPSRL---P 485
            ||||||||:||:.|:|.|.:..:..||.                          ..||.|.   |
  Fly   440 GPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDP 504

Human   486 IKMPQLVLRSKNGFHLHLK 504
            |....|.|:|:||.::.||
  Fly   505 ILSAVLTLKSENGLYIRLK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	158/507 (31%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	148/455 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650