Protein Alignment CYP4B1 and Cyp4e2

DIOPT Version :10

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 167/539 - (30%)
• Similarity: 258/539 - (47%)
• Gaps: 76/539 - (14%)

Human    20 LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGS--LDKVVSWAHQFPYAH- 81
            :.|.|..|.:.:|.|......:.::||.||....|.|:|.::.:..|  ||.|.||.||:...:
  Fly     7 IFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNF 71

Human    82 PLWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPG 144
            ..|.|.:...| :....|.:.:.|...  .|: |:|.....|:|.|||...|.||.:|||::||.
  Fly    72 VFWIGTYSNVL-VTSSKYLEFILSSQTLITKS-DIYQLTHPWLGLGLLTSTGSKWHKHRKMITPA 134

Human   145 FHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLG---- 205
            ||:::|:.:..|..|::...:...:..|.....||......::.|:.:  |     ||.:|
  Fly   135 FHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI--C-----DTAMGVSIN 192

Human   206 --HSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAA 268
              .:|.||...|..|:...:..|.......|:.:|.|.|....:.|..:...|.|:::|.:|..|
  Fly   193 AMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEA 257

Human   269 LQ---------DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSG 324
            .:         ||..|||      :.|||.||.: ..|...|:..:|..||.|||||||||||||
  Fly   258 HKSGAVSTNAGDEFTRKK------MAFLDTLLSS-TIDGRPLNSKELYEEVSTFMFEGHDTTTSG 315

Human   325 ISWFLYCMALYPEHQHRCREEVREILGDQDF-----FQWDDLGKMTYLTMCIKESFRLYPPVPQV 384
            :|:.:|.::.:.:.|.:..:|.||::|:.:.     ||  ::.:|.||.:.|||:.|:||.||.:
  Fly   316 VSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQ--EISQMKYLDLFIKEAQRVYPSVPFI 378

Human   385 YRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 449
            .|...|... :||..:|.|:.:::.:..|..|..|:.||..|...||..|   |..||.::||||
  Fly   379 GRFTEKDYV-IDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELE---KPGPFEYVPFSA 439

Human   450 GPRNCIGQQFAMSEMKVVTAMCLLRFEF--------------------------SLDPSRL---P 485
            ||||||||:||:.|:|.|.:..:..||.                          ..||.|.   |
  Fly   440 GPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDP 504

Human   486 IKMPQLVLRSKNGFHLHLK 504
            |....|.|:|:||.::.||
  Fly   505 ILSAVLTLKSENGLYIRLK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	152/486 (31%)
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	145/473 (31%)