Protein Alignment CYP4B1 and Cyp4d21

DIOPT Version :10

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 162/528 - (30%)
• Similarity: 260/528 - (49%)
• Gaps: 59/528 - (11%)

Human    15 LWASGLILVLGFLKLIHLLL----RRQTLAKAMDK--FPGPPTHWLFGH---ALEIQETGSLDKV 70
            :|     ::||...||..|:    |:|......:|  ..||.|..:.|:   ||.::....:.:.
  Fly     1 MW-----ILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRF 60

Human    71 VSWAHQFPYAHPLWFGQFIGFLNIYEPD--YAKAVYSRGD-PKAPDVYDFFLQWIGRGLLVLEGP 132
            ..:.:::.....||   .:|...||..|  |.:::.|... .|...:|.|...::|.|||:..|.
  Fly    61 GDYFNKYGKTFRLW---ILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGN 122

Human   133 KWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALNTLMKCT 196
            ||...||:|.|.||:..|:.:|.:...::.||::|.:..| :||: .|:|..|...||:...:..
  Fly   123 KWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYA-DGKTCVDLFKFVSLEALDVTTETA 186

Human   197 FGRGDTGLGHSRDSSYYLAVSDLTLLMQQRL--VSFQYHNDFIYWLTPHG-----RRFLRACQVA 254
            .| ......:..:..|..|:..:..:..:||  ||.:|:     ||.|..     ||..:...:.
  Fly   187 MG-VQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYN-----WLFPLAAPLVYRRLQKDIAIM 245

Human   255 HDHTDQVIRERKAALQDEKVR------------KKIQNRRHLDFLDILLGARDEDDIKLSDADLR 307
            .|.||:|||||:|.|  |:.|            ..|..:..:..|||||.| ..|:..|||.|:|
  Fly   246 QDFTDKVIRERRAIL--ERARADGTYKPLIMGDDDIGGKAKMTLLDILLQA-TIDNKPLSDVDIR 307

Human   308 AEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG---DQDFFQWDDLGKMTYLTM 369
            .|||.|:|.|.||||||:|..|:.::.:|:.|....||:..:||   |....| ..|.::.||..
  Fly   308 EEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQ-TKLLELKYLDC 371

Human   370 CIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRF-ST 433
            .|||:.||:||||.:.|.:.:.:. :...::|..:.|.:..|.::|:...:|||.||...|: ..
  Fly   372 VIKETMRLHPPVPILGRYIPEDLK-IGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDM 435

Human   434 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKN 497
            :..|...|.|::|||:||:|||||:||..:||.:.:..:..:|  |.|....:|.. ..:|.|..
  Fly   436 KTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYE--LLPLGADLKATYTFILSSST 498

Human   498 GFHLHLKP 505
            |.::.|||
  Fly   499 GNNVGLKP 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	144/462 (31%)
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	144/450 (32%)