DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP4B1 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	141/504 - (27%)
Similarity:	247/504 - (49%)	Gaps:	70/504 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    15 LWAS--GLILVLGFLKLIHLLLRR-------QTLAKAMDKFPGPPTH---------WLFGHALEI 61
            :|.:  |..|::|.|   .||||:       .:|.|.:....|.|..         ..||:.|::
  Fly     1 MWIALLGSSLLIGAL---WLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDL 62

Human    62 QETGSLDKVVSWAHQFPYAHP----------LWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDV-Y 115
            ..       ::.|:.|.|...          :|...|....||...:.|:.::........:: |
  Fly    63 LN-------LTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKITTKNMSY 120

Human   116 DFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTR---IMLDKWEEKAREGKS 177
            :....::|.|||:....||...||.|||.||:::|:.::::|.|.::   .:|||     ..|..
  Fly   121 ELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDK-----NVGFE 180

Human   178 FDIFCDVGHMALNTLMKCTFGRGDTGLG-----HSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFI 237
            .::...:....||.:  |     :|.||     .|..:.|..|:.|..::..||:.:.....::.
  Fly   181 LELNQIIPQFTLNNI--C-----ETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWY 238

Human   238 YWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRK--KIQNRRHLDFLDILLGARDEDDIK 300
            ::|....:::.|..:..|..:..:|:.::...:.:::.:  :...::....||.||.|..|.  |
  Fly   239 FFLFGDYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEG--K 301

Human   301 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD---FFQWDDLG 362
            :....:..||:||||.|:|||::.:.:.|..:||:.:.|.||.||::::..|.|   .||:::|
  Fly   302 IDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMFQFNEL- 365

Human   363 KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFD 427
              .:|...||||.||:|..|.:.|...:. :.::|..||..:.||:|||.:.|::..:|.|..|.
  Fly   366 --IHLECVIKESLRLFPSAPIIGRTCIEE-SVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFL 427

Human   428 SLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 476
            ..||..||:..||||||:||||||||||||:|.:.|:||:.|..:..|:
  Fly   428 PERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFK 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	130/463 (28%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	128/451 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850