Protein Alignment CYP4B1 and Cyp311a1

DIOPT Version :10

• Sequence 1: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 150/520 - (28%)
• Similarity: 248/520 - (47%)
• Gaps: 73/520 - (14%)

Human    13 LGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDK------VV 71
            :.||...||.:     .|.:|:|:.||.:.....|||....|.|:|   |..|.|..      ..
  Fly     1 MALWPLLLITL-----TIWILVRKWTLLRLGSSLPGPWAFPLLGNA---QMVGKLRPEYIFLVFT 57

Human    72 SWAHQFPYAHPLWFG-QFIGFLN--------IYEPDYAKAVYSRGDPKAPDVYDFFLQ---WIGR 124
            ....:|...:.|..| |...||:        :::|...||             |.|:|   .||.
  Fly    58 ELRDRFGATYRLRLGPQLWVFLHSAEETRQALHDPTLRKA-------------DTFMQLEPLIGN 109

Human   125 GLLVLEGPKWLQHRKLLTPGFHYDVLKPYV-AVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMA 188
            |||:..|..|.:.|:||||.|...:|:.:. |:.....|::       .|.|.:...|.:|....
  Fly   110 GLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLV-------GRLGATRGAFLEVTEPL 167

Human   189 LNTLMKCTFGRGDTGLGHSRDS----------SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPH 243
            ...|:....   ||.:|...|:          :::|:    :.|:.:|:::....:|:|:..|..
  Fly   168 FACLLDAIV---DTSMGAQLDTQSVDHSPIIQAFHLS----SKLLFKRMINPLLSSDWIFQRTQL 225

Human   244 GRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRA 308
            .|......||.|...:.||.:|...|.|   ..:...|.| :.||.||.|:.|.. .||..::|.
  Fly   226 WRDLDEQLQVIHSQMESVIEKRAKELLD---MGEPAGRAH-NLLDTLLLAKFEGQ-SLSRREIRD 285

Human   309 EVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKE 373
            |::||:|.|.||||:.:|:.||.:|.:||.|.|.|:|::::..|:. ...|.|..:.||...|||
  Fly   286 EINTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALDET-TDLDALNGLPYLEALIKE 349

Human   374 SFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASK 438
            ..|||..||...||.::. |.:.||:..||..:.:::|.|..:...:|||..|...|:..|:.:.
  Fly   350 VLRLYTIVPTTGRQTTQS-TEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAV 413

Human   439 RHP-FAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKM-PQLVLRSKNGFHL 501
            ..| |:::|||.||..|||:::::..||::||..:..|:..|.|.:.|::: .|:||:::.|.::
  Fly   414 APPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINV 478

Human   502  501
              Fly   479  478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	133/466 (29%)
Cyp311a1	NP_572780.3	cytochrome_P450	64..478	CDD:477761	131/447 (29%)