Protein Alignment CYP4A11 and Cyp6a17

DIOPT Version :9

• Sequence 1: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Sequence 2: NP_001286433.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 134/538 - (24%)
• Similarity: 244/538 - (45%)
• Gaps: 85/538 - (15%)

Human    18 ILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRI-----QK 77
            :|..|.::::|.||:.|.: ..|..|..:.:   |....|.|||:|::....:.:..|     .|
  Fly     1 MLLLALIVVILSLLVFAAR-RRHGYWQRRGI---PHDEVHPLFGNIKDWPNKRHIAEIFRDYYFK 61

Human    78 WVET-FPSACPHWLWGGKVRVQLYDPDYMKVILGR--SDPKSHG-SYRFLAPWIGYGLLLLNGQT 138
            :..: :|.|...:.:.....|.  |.:.:|.:|.:  :..::.| .|..:...:...|..:.||.
  Fly    62 YKNSDYPFAGFFFFFTRTAVVT--DMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFSIEGQK 124

Human   139 WFQHRRMLTPAFHYDILK---PYVGLMADSV-RVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMK 199
            |...|..|||.|....:|   |.|..:.:.: :|...|.....||  .|||...|:..|.|.|..
  Fly   125 WRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQ--VLEVVDLVARYTADVIGN 187

Human   200 CAFSHQGSIQVDRNSQSYI----QAISD------LNNLVFS--------RVRNAFHQNDTIYSLT 246
            |||....:...|..:: ::    :||::      |:..:|.        |::....:.:..|:
  Fly   188 CAFGLNCNSLYDPKAE-FVSIGKRAITEHRYGNMLDIFLFGFPKLSRRLRLKLNIQEAEDFYT-- 249

Human   247 SAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILL-------LAKMENGS 304
                      ::..:..|..:              :.|.||: ||:|.|:       ....|:|
  Fly   250 ----------KIVRETIDYRL--------------RTKEKRN-DFMDSLIEMYKNEQSGNSEDG- 288

Human   305 ILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLG-DGASITWNHLDQ 368
             |:..:|.|:...|...|.:|:::.:.:.||.||.:...|::.||||.::.| .....|:..:.:
  Fly   289 -LTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKE 352

Human   369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFD 432
            |.|....:.|.||.||.:..:.|...|..:..|.: .:.||.:|::...|:|::|.::|.||:|.
  Fly   353 MKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFK 417

Human   433 PFRFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTL--LRFELLPDPTRIP--IPI 491
            |.||...  :|:.|..:|||..|.|||||.:|.|.:..|..|..:  .:|.:.|: |:||  |.:
  Fly   418 PERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPE-TQIPMKIVV 481

Human   492 ARLVLKSKNGIHLRLRRL 509
            ..:::.::|||||::.:|
  Fly   482 KNILISAENGIHLKVEKL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	124/498 (25%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	118/476 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810