DRSC/TRiP Functional Genomics Resources

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Protein Alignment CYP4A11 and Cyp4p1

DIOPT Version :9

Sequence 1:NP_000769.2 Gene:CYP4A11 / 1579 HGNCID:2642 Length:519 Species:Homo sapiens
Sequence 2:NP_524828.1 Gene:Cyp4p1 / 45524 FlyBaseID:FBgn0015037 Length:513 Species:Drosophila melanogaster


Alignment Length:539 Identity:146/539 - (27%)
Similarity:254/539 - (47%) Gaps:82/539 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    24 LLILLLLLIKAVQLYLHRQWLLKALQQF----------------------PCPPSHWLFGHIQEL 66
            ::||.|:|..:..||    ||.:|.:.:                      |......:||:..:|
  Fly     1 MIILWLILALSALLY----WLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDL 61

Human    67 -----------QQDQELQRIQKWVE-TFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHG- 118
                       .:::..:....::| .|          ||....:.|.|..:.:|...:..:.| 
  Fly    62 YGRDHAGVFNYSRERAKEMGTSYIEYVF----------GKAIYNIIDADSAENVLNHPNLITKGL 116

Human   119 SYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDS-P 182
            .|.||.|::..|||...|:.|...|:||||.||::||..:..:.....:..|.::|   |||. .
  Fly   117 VYNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQFE---GQDEVT 178

Human   183 LEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQS---YIQAISDLNNLVFSRVRNAFHQNDTIYS 244
            :.:...:...||::|.:.|.    .:::|..::.   |.:..|.:......|:.|.....|.::.
  Fly   179 ITLHDVIPRFTLNSICETAM----GVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFE 239

Human   245 LTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK----------IKRKRHLDFLDILLLAK 299
            :.:|..:. .|..:.|:.:.::|..|:..|  :.||:|          :.:|| ...||.|:.| 
  Fly   240 MFAAKDFA-SALDVVHRFSSEIIAKRRDLL--KDELDKSSSTADDDGFVSKKR-FAMLDTLIYA- 299

Human   300 MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS-ITW 363
             |...::....:..||||.||||:|||:.|:.:.|..::.:|..||.|.:||...:.|..| :..
  Fly   300 -EKDGLIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSNLDV 363

Human   364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
            ..|:::.|....:||..||:|.||.:|||........:|..||||..:.:.::.:|.|.|.|.:|
  Fly   364 GQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDSP 428

Human   429 EVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP--DPTRIPI 489
            |.|.|.||.|.:.|  |::|::|||.|.||||||::||.|:|....:.|.:|::|.  ||.:|..
  Fly   429 EEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVF 493

Human   490 PIARLVLKSKNGIHLRLRR 508
            ... :.|::::.|.::|.|
  Fly   494 HTG-ITLRTQDKIRVKLVR 511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYP4A11NP_000769.2 p450 52..505 CDD:278495 135/484 (28%)
Cyp4p1NP_524828.1 p450 54..509 CDD:278495 134/478 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154854
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1247045at2759
OrthoFinder 1 1.000 - - FOG0000016
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X23
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.850

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