Protein Alignment CYP4A11 and Cyp312a1

DIOPT Version :9

• Sequence 1: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Sequence 2: NP_001262008.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 478
• Identity: 144/478 - (30%)
• Similarity: 236/478 - (49%)
• Gaps: 30/478 - (6%)

Human    30 LLIKAVQLYL----HRQWLLKAL-QQFPCPPSHWLFGHIQ---ELQQDQELQRIQKWVETFPSAC 86
            ||:.|:.|||    .||..:..| .::|.||:....||:.   :|.....|:|..:.:.......
  Fly     8 LLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINEHLHDH 72

Human    87 PHWLWGGKVRVQLYD---PDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTP 148
            ...||.| .::.|.|   .|...:...:...:....||....|:..||.....:.|...|:::.|
  Fly    73 RAKLWMG-TKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWSHRRKIVMP 136

Human   149 AFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRN 213
            ||:|.::|.:|.:.....|::|....:.......::..|.:|..|||||.:.|.......|....
  Fly   137 AFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALGVSVGSQSSAK 201

Human   214 SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQK-- 276
            |: |:.|:..:..::..|::|.|::|..|:..||..:......:..|..|:.:||.|..::.:
  Fly   202 SE-YLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDA 265

Human   277 --------EGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWI 333
                    :.||:.:||.  |.|||.|||:|..:|..|:.||:|.||||.:|.|.|.||:.:::.
  Fly   266 ENRNYQSSDAELDGVKRT--LCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFF 328

Human   334 LYALATHPKHQERCREEIHSLLGDGAS--ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTP 396
            :|.:..||:||:|||||:.|:.|...|  |:...:.|:.:...||||.||:||..|...|:.:..
  Fly   329 MYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATAN 393

Human   397 VTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHA--FLPFSGGSRNCIG 459
            .|..| ..:|||..|::|...:......:|:|.||.|.|:|.|:.....|  |:||..|:|:|:|
  Fly   394 CTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMAGARSCMG 457

Human   460 KQFAMNELKVATALTLLRFELLP 482
            :::||..||:..|..|..|...|
  Fly   458 QRYAMVMLKMVLAHLLRNFLFEP 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	135/451 (30%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	135/451 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154748
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750