DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP4A11 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	133/547 - (24%)
Similarity:	230/547 - (42%)	Gaps:	108/547 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    18 ILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRI-QKWVET 81
            :.|.|..|:.:|      ..|:||:......:..|....|.:.|:::|||:.:.:..| |.....
  Fly     7 LFQVAVALLAIL------TYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNK 65

Human    82 F-PSACPH--WLWGGKVRVQLYDPDYMKVIL---------------GRSDPKSHGSYRFLAPWIG 128
            | .|..|.  :.:.......:.|.:..|.||               .:.||            |.
  Fly    66 FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDP------------IS 118

Human   129 YGLLLLNGQTWFQHRRMLTPAF---HYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVS 190
            ..|..|:|..|...|..|:..|   ...::.|.|..:|:....::   .|.:.::|.||:...|:
  Fly   119 AHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVM---HEKVPKNSVLEIRDLVA 180

Human   191 LMTLDTIMKCAFSHQ-GSIQVDRNSQSYI--QAISD------LNNLVFS---------RVRNAFH 237
            ..|:|.|..|||..| .|::.::....|.  :::.|      ||..:.|         .||.|.|
  Fly   181 RFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPH 245

Human   238 QNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK--- 299
            ..: .||                :...:.:.:|        |.|.|||.   ||:|:|:..|
  Fly   246 IQE-FYS----------------RIVTETVAVR--------EKEHIKRN---DFMDMLIELKNQK 282

Human   300 ---MENGSI---LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGD- 357
               :|||.:   |:.:::.|:...|...|.:|::|.:.:.||.||.:|..|::.|.|:..::..
  Fly   283 EMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQH 347

Human   358 GASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRS--LPKGIMVLLSIYGLHH 420
            ..:.|:.....:.|....:.|.||||..||.:.|..:.....|...:  :..|..|::....:||
  Fly   348 DQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHH 412

Human   421 NPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPD 483
            :|.::|.|..|.|.||:|  .:.:.|.|:|||..|.|||||.:|...:.::..||.:..|: ...
  Fly   413 DPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK-FST 476

Human   484 PTRIPIPIA----RLVLKSKNGIHLRL 506
            .::.|.|:.    ..||..|:||:|::
  Fly   477 CSKTPNPLVYDPKSFVLGVKDGIYLKV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	125/510 (25%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	125/507 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900