DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4A11 and Cyp6a21

DIOPT Version :9

Sequence 1:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	127/525 - (24%)
Similarity:	224/525 - (42%)	Gaps:	53/525 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    15 VSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRI-QKW 78
            |..:|..|.|.::..||:|......|.|.|     ..||...|.|.|.::.::..:....| ..:
  Fly     3 VGTVLLTALLALVGYLLMKWRSTMRHWQDL-----GIPCEEPHILMGSMKGVRTARSFNEIWTSY 62

Human    79 VETFPSACPH--WLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPW---IGYGLLLLNGQT 138
            ...|..:.|.  :.|..:..|.:.:....|.||.:...|......|..|.   :...|.||:||.
  Fly    63 YNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQLFLLDGQK 127

Human   139 WFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD---SP-LEVFQHVSLMTLDTIMK 199
            |...|..|:..|....:|    .|..:|..:.:::.::.||:   || :||.:.::..|.|.|..
  Fly   128 WRTMRNKLSSTFTSGKMK----YMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGT 188

Human   200 CAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTD 264
            |||..:.|...|.:::........|.......|...|     :.|..:..|..|.      :.|.
  Fly   189 CAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGF-----VNSFPNLARRLHM------KMTA 242

Human   265 QVIQLRKAQLQKE----GELEKIKRKRHLDFLDIL-------LLAKMENGSI-LSDKDLRAEVDT 317
            :.|:....::.:|    .|...|:|.   ||:|.|       |:......|: |:.:::.|:...
  Fly   243 EPIERFFMRIVRETVAFREQNNIRRN---DFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFV 304

Human   318 FMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGD-GASITWNHLDQMPYTTMCIKEALR 381
            |...|.:|:::.:.:.||.||.:...|.|.|:|...::.. ...:.:..:..:.|....:.|.||
  Fly   305 FFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLR 369

Human   382 LYPPVPGIGRELSTPVTFPDGRS--LPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQH- 443
            ||..:|.:.||.......|....  :.||:.||:....:|.:.|::.||..|:|..|:|...:.
  Fly   370 LYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKER 434

Human   444 -SHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL-LPDPTRIPIPIAR--LVLKSKNGIHL 504
             |..:|||..|.|||||.:|...:.::..||.:..|:. :.:.|.||:...:  .::.|.:||:|
  Fly   435 DSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNSGIYL 499

Human   505 RLRRL 509
            :..|:
  Fly   500 KAERV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	115/482 (24%)
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	115/481 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900