Protein Alignment CYP4A11 and Cyp6a19

DIOPT Version :9

• Sequence 1: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Sequence 2: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 147/534 - (27%)
• Similarity: 234/534 - (43%)
• Gaps: 72/534 - (13%)

Human    11 LLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRI 75
            |||.|.|:|...:..:|        |.|.:  |..:.:   |..|.:...|:..||.:...|..|
  Fly     4 LLGLVVGVLTLVAWWVL--------QNYTY--WKRRGI---PHDPPNIPLGNTGELWRTMPLAGI 55

Human    76 QKWV------ETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSH--GSYRFLA--PWIGYG 130
            .|..      :|.......:|:..|. :.:.|.|::|.:|.|...|.|  |.|....  | :...
  Fly    56 LKRTYLKFRKQTDGPFAGFYLYAMKY-IVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDP-LTNN 118

Human   131 LLLLNGQTWFQHRRMLTPAFHYDILKPYVGL---MADSVRVMLDKWEELLGQDSPLEVFQHVSLM 192
            |..:.||.|...|:.||..|....:|.....   :.|.:..::|  |::......|||...||..
  Fly   119 LATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVD--EKISSSSQTLEVTDIVSRF 181

Human   193 TLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQ 257
            |.|.|..|||..:.:...|..:: ::|       :.:|.:|...|  ..:..|...| ....|.:
  Fly   182 TSDVIGICAFGLKCNSLRDPKAE-FVQ-------MGYSALRERRH--GWLVDLLIFG-MPKLAVK 235

Human   258 LAHQHTDQVIQLRKAQLQKEGELEKIKRK-RHLDFLDILLLAKM-------ENGSILSDKDLRAE 314
            |..|.....:|....::.::....::||| ...||:|.|:..|.       |||  |:..::.|:
  Fly   236 LGFQFLLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENG--LAFNEVAAQ 298

Human   315 VDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGD-GASITWNHLDQMPYTTMCIKE 378
            ...|...|.:..::.:.:.||.||.:...|::.|.||.|:|.. ...:.::.:..:.|....|.|
  Fly   299 AFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINE 363

Human   379 ALRLYPPVPGIGRELSTPVTFPDGRSLPK-----GIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP 438
            :||.:|.|..:.|    ..|.|...|.||     |..||:|..|:||:|:.:|.||.|.|.||..
  Fly   364 SLRKHPVVAHLAR----IATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDE 424

Human   439 GSAQH--SHAFLPFSGGSRNCIGKQFAMNELKVATALTL--LRFELLPDPTRIPIP----IARLV 495
            ...:.  :.|||||..|.|||||.:|...::.:..||.:  .||||.|   :.|:|    |..|:
  Fly   425 EQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHP---KTPVPMKYTINNLL 486

Human   496 LKSKNGIHLRLRRL 509
            |.|:.||||.:.::
  Fly   487 LGSEGGIHLNITKV 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	136/487 (28%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	135/486 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900