DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4A11 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	149/556 - (26%)
Similarity:	229/556 - (41%)	Gaps:	119/556 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    23 SLLILLLLLIKAVQLYLHRQWLLKALQQF---------PCPPSHWLFGHIQELQQDQELQRIQKW 78
            |::.|.|.:|..|.||   :|.:.....|         |.|    |.|:|........:..::|.
  Fly     4 SMIALALFIILLVLLY---KWSVAKYDVFSERGVSHEKPWP----LIGNIPLKAMIGGMPVLKKM 61

Human    79 VETFPSACPHWLWGGKVRVQLY----------DPDYMKVI-LGRSDP-KSHGSY--RFLAPWIGY 129
            :|.      |....|.....:|          ||:.:|:| :...|. .:|.|.  ......:..
  Fly    62 IEL------HTKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSK 120

Human   130 GLLLLNGQTWFQHRRMLTPAF-------HYDILKPYVGLMADSVRVMLDKWEEL-LGQDS--PLE 184
            .|:.|....|.:.|.:|||||       .||:::      :.|...::...|:| |.||:  .||
  Fly   121 SLISLRDGRWKEMRNILTPAFTGSKMRIMYDLIQ------SCSEEGVIHIQEQLELSQDASIELE 179

Human   185 VFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAG 249
            :..:.:....|.|...||.      :..||              |.|..|.|.:.....|..||
  Fly   180 MKDYFTRFANDVIATVAFG------ISINS--------------FRRKDNEFFRIGQAMSRISA- 223

Human   250 RWT----------------HRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLA 298
             |:                .|...|..::.|....|..|.::...| .|:.|.   |.:.:|:.|
  Fly   224 -WSVVKAMLYALFPRLMKVLRIQVLDTKNIDYFSSLVTAAMRYRQE-HKVVRP---DMIHLLMEA 283

Human   299 KMENGSILSDK-------------DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREE 350
            |.:..:.||||             ||.|:...|.|.|.:..:|.:.::.:.|..:|..|:|..||
  Fly   284 KQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEE 348

Human   351 IHSLLGD--GASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPD--GRSL---PKG 408
            |.|:..:  |..:|::.|.:|.|..|.:.||||.:||.....||....:...|  |:.|   .||
  Fly   349 IISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKG 413

Human   409 IMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATAL 473
            .::.:.|:.|||:|:.:.:||.|:|.|||.|.|..|..::||..|.|||||.:.|:.|||.....
  Fly   414 DVLQIPIFSLHHDPENFEDPEFFNPERFADGHALESRVYMPFGVGPRNCIGNRMALMELKSIVYQ 478

Human   474 TLLRFELLPDPTRIPIPIARLV----LKSKNGIHLR 505
            .||.|:||| ..|....:...:    ||.|||..|:
  Fly   479 LLLNFKLLP-AKRTSRDLLNDIRGHGLKPKNGFWLK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	139/516 (27%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	139/516 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900