DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4A11 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	161/533 - (30%)
Similarity:	260/533 - (48%)	Gaps:	68/533 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    25 LILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQD--QELQRIQKWVETF-PSAC 86
            |.|.|||:..::|...|:  .:.|.:|..|....|.|:..::.::  :.|..:..|...: ....
  Fly     9 LALPLLLVAYLELSTFRR--RRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNF 71

Human    87 PHWLWGGKVRVQLYDPDYMKVILG------RSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRM 145
            ..|: |....|.:....|::.||.      :||     .|:...||:|.|||...|..|.:||:|
  Fly    72 VFWI-GTYSNVLVTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTGSKWHKHRKM 130

Human   146 LTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQ- 209
            :|||||::||:.:..:|.::....:...:.:...|:..:..:....:|||.|  |..:...||.
  Fly   131 ITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI--CDTAMGVSINA 193

Human   210 VDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQL 274
            ::..|.|.:||..|:...:..|..:...:|:.:|.|........|..:.....|:::| .::.:.
  Fly   194 MENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEII-AKRIEA 257

Human   275 QKEGEL-----EKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL 334
            .|.|.:     ::..||: :.|||.||.:.:: |..|:.|:|..||.||||||||||.||:|:.:
  Fly   258 HKSGAVSTNAGDEFTRKK-MAFLDTLLSSTID-GRPLNSKELYEEVSTFMFEGHDTTTSGVSFAV 320

Human   335 YALATHPKHQERCREEIHSLLGD---GASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTP 396
            |.|:.|...|.:..:|...::|:   |...|:..:.||.|..:.||||.|:||.||.|||.....
  Fly   321 YLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKD 385

Human   397 VTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRF---APGSAQHSHAFLPFSGGSRNCI 458
            ... ||..:|||..:.|.:..|.:|.||:.:|..|.|.||   .||..:    ::|||.|.||||
  Fly   386 YVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPGPFE----YVPFSAGPRNCI 445

Human   459 GKQFAMNELKVATALTLLRFELLP--------------------------DPTR---IPIPIARL 494
            |::||:.|:|...:..:..||:||                          ||.|   .||..|.|
  Fly   446 GQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVL 510

Human   495 VLKSKNGIHLRLR 507
            .|||:||:::||:
  Fly   511 TLKSENGLYIRLK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	150/502 (30%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	136/449 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650