Protein Alignment CYP4A11 and Cyp4d21

DIOPT Version :9

• Sequence 1: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Sequence 2: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 491
• Identity: 152/491 - (30%)
• Similarity: 252/491 - (51%)
• Gaps: 45/491 - (9%)

Human    24 LLILLLLLIKAVQLYLHRQWLLKALQQ------FPCPPSHWLFGH-IQ--ELQQDQELQRIQKWV 79
            ||.:.:|::..|.....:||.:...::      |..|    :.|: :|  .|:.:..:||...:.
  Fly     4 LLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIP----IVGNGLQALTLRPENFIQRFGDYF 64

Human    80 ETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSD--PKSHGSYRFLAPWIGYGLLLLNGQTWFQH 142
            ..:......|:. |:..:...|..|.:.||..|.  .|:| .||||..::|.||||..|..|...
  Fly    65 NKYGKTFRLWIL-GECLIYTKDLKYFESILSSSTLLKKAH-LYRFLRDFLGDGLLLSTGNKWTSR 127

Human   143 RRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
            |::|.||||:..|:.:|.:|..:..:|::|.:......:.:::|:.|||..||...:.|...|.:
  Fly   128 RKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVN 192

Human   208 IQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQ----LAHQHTDQVIQ 268
            .|.:.|. .|.:|:..:..:...|:.:...:.:.::.|  |....:|..|    :....||:||:
  Fly   193 AQNEPNF-PYTKALKSVVYIESKRLASVSMRYNWLFPL--AAPLVYRRLQKDIAIMQDFTDKVIR 254

Human   269 LRKAQLQKE-----------GELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEG 322
            .|:|.|::.           |: :.|..|..:..|||||.|.::| ..|||.|:|.|||.|:|.|
  Fly   255 ERRAILERARADGTYKPLIMGD-DDIGGKAKMTLLDILLQATIDN-KPLSDVDIREEVDVFIFAG 317

Human   323 HDTTASGISWILYALATHPKHQERCREEIHSLLG--DGASITWNHLDQMPYTTMCIKEALRLYPP 385
            .|||.||:|..|:|::.|||.||...||:.|:||  ..||:|...|.::.|....|||.:||:||
  Fly   318 DDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPP 382

Human   386 VPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSH---A 446
            ||.:||.:  |.....|. ::|....:||..|.::.:|:.:|:|.||.|.|:.......:.   |
  Fly   383 VPILGRYI--PEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLA 445

Human   447 FLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
            ::|||.|.:||||::||..::|...:..:..:||||
  Fly   446 YIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLP 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	145/457 (32%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	146/460 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750