DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4A11 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	146/536 - (27%)
Similarity:	262/536 - (48%)	Gaps:	66/536 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQL-----YLHRQWLLKALQQF-------PC 53
            |.:::|..|.|:|.:..:|:..:....:|.|.|.|:.     ...:.:::....:|       ..
  Fly     1 MWIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNL 65

Human    54 PPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPK--- 115
            .|:: :|.:|:|              .|..:...:::|.     .|:.|:|.  |:...|.:
  Fly    66 TPAN-IFSYIRE--------------STAKANGQNYIWN-----FLFAPEYN--IVRAEDAEEIF 108

Human   116 -------SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKW 173
                   .:.||..:.|::|.|||:...|.|...|:.||||||::||:.::.:..:..:..:...
  Fly   109 QSTKITTKNMSYELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKIL 173

Human   174 EELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQ--SYIQAISDLNNLVFSRVRNAF 236
            ::.:|.:  ||:.|.:...||:.|.:.|.    .:::|..|:  .|.:||.|...:...|:.|..
  Fly   174 DKNVGFE--LELNQIIPQFTLNNICETAL----GVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPL 232

Human   237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKE--GELEKIKRKRHLDFLDILLLAK 299
            ...:..:.|....:...|..:..|..:..:||.::.|.:::  |::::..:|:....||.||.|:
  Fly   233 MFFNWYFFLFGDYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAE 297

Human   300 MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWN 364
            .| |.| ..:.:..||:||||.|:|||::.:.:.|..||.|...||||.||:..|..|...::..
  Fly   298 AE-GKI-DHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMF 360

Human   365 HLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPE 429
            ..:::.:....|||:|||:|..|.||| .....:..:|..|||...:.:.||.:..:.:.:|.|.
  Fly   361 QFNELIHLECVIKESLRLFPSAPIIGR-TCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPN 424

Human   430 VFDPFRFAPGSA--QHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIA 492
            .|.|.||.|.::  :|..||:|||.|.|||||::|.:.|:||..|..:..|:||| .|::.
  Fly   425 QFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLP-ATQLE---- 484

Human   493 RLVLKSKNGIHLRLRR 508
              .|..:|||.||.::
  Fly   485 --DLTFENGIVLRTQQ 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	133/468 (28%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	136/486 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850