Protein Alignment CYP4A11 and Cyp4s3

DIOPT Version :10

• Sequence 1: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Sequence 2: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Alignment Length: 509
• Identity: 181/509 - (35%)
• Similarity: 274/509 - (53%)
• Gaps: 43/509 - (8%)

Human    22 ASLLILLLLLIKAVQLYLHRQWLLKALQQF----PCPPSHWLFGHIQELQQDQELQRIQKWVETF 82
            ::|.::..:|..|...||.:......||:|    |.|.       |.||..:.:...|..|::..
  Fly     2 STLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPT-------IGELIANVKKGEILNWLKEL 59

Human    83 PSACPHW----LWGGK-VRVQLYDPDYMKVILGRSD--PKSHGSYRFLAPWIGYGLLLLNGQTWF 140
            ..  .|.    :|.|| :.|...||:.:|.:||.:.  .||. :|..|.||:|.|||...|::|.
  Fly    60 RE--KHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSR-NYELLEPWLGKGLLTNGGESWH 121

Human   141 QHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQ 205
            :.|::|||.||:.||..:...|.::.|:::.:.......:| .:::.:::|..||.|.:.|...:
  Fly   122 RRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFALDAICETAMGIK 185

Human   206 GSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLR 270
            ...|:..:|: |:||:..:..::..:..:.:.:.:..:..|..|:....|.::.|..|::||:||
  Fly   186 KHAQLQSDSE-YVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLR 249

Human   271 KAQL-------QKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTAS 328
            :.||       :.|.|.:.:..||.|.|||:|||.:||.|:.|||.|:|.|||||||||||||:|
  Fly   250 REQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSS 314

Human   329 GISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGREL 393
            .|::.|..|:.:|..|:|..||...|.|       ...:.|||....|||.||:||.||...|::
  Fly   315 AIAFALSLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYPSVPFFSRKV 372

Human   394 STPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ-HSHAFLPFSGGSRN 456
            ...:..  |: ::|||..:...||.||.:||.:|:||.|||.||.....| |..||..||.|.||
  Fly   373 LEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRN 435

Human   457 CIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRLP 510
            |||::|||.|||.:.|:.|..:..|||....|.|:|.||.||.|||  |||.||
  Fly   436 CIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGI--RLRILP 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	163/446 (37%)
Cyp4s3	NP_573003.2	CYP4	64..483	CDD:410721	160/432 (37%)