DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4A11 and Cyp311a1

DIOPT Version :9

Sequence 1:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	158/501 - (31%)
Similarity:	253/501 - (50%)	Gaps:	53/501 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    29 LLLIKAVQLYLHRQW-LLKALQQFPCPPSHWLFGHIQ---ELQQD------QELQRIQKWVETFP 83
            ||||......|.|:| ||:.....|.|.:..|.|:.|   :|:.:      .||:  .::..|:.
  Fly     6 LLLITLTIWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELR--DRFGATYR 68

Human    84 SACPHWLW-----GGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHR 143
            ......||     ..:.|..|:||...|.          .::..|.|.||.|||:.:|..|.:.|
  Fly    69 LRLGPQLWVFLHSAEETRQALHDPTLRKA----------DTFMQLEPLIGNGLLISHGAHWTRQR 123

Human   144 RMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLG-----QDSPLEVFQHVSLMTLDTIMKCAFS 203
            |:|||||...:|:.:...:...|       |.|:|     :.:.|||.:.:....||.|:..:..
  Fly   124 RLLTPAFQPQLLRSFAPAIGGHV-------ERLVGRLGATRGAFLEVTEPLFACLLDAIVDTSMG 181

Human   204 HQGSIQ-VDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267
            .|...| ||.:  ..|||....:.|:|.|:.|....:|.|:..|...|......|:.|...:.||
  Fly   182 AQLDTQSVDHS--PIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVI 244

Human   268 QLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISW 332
            :.|..:|...||    ...|..:.||.|||||.| |..||.:::|.|::||:|.|.|||.:.:|:
  Fly   245 EKRAKELLDMGE----PAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAMSF 304

Human   333 ILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPV 397
            :|||||..|:.|.|.|:|:..:..| .:...:.|:.:||....|||.||||..||..||: :|..
  Fly   305 VLYALAKFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQ-TTQS 367

Human   398 TFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP---GSAQHSHAFLPFSGGSRNCIG 459
            |...||:...|:.:.:::|||.|:.:.:|:|..|.|.|:.|   ..|..:.:::|||||...|||
  Fly   368 TEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIG 432

Human   460 KQFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHL 504
            :::::..:|:.||..:..|::...|.:.|:.: |::|||::.||::
  Fly   433 RRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINV 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	149/477 (31%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	149/477 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810