Protein Alignment CYP4A11 and Cyp4ae1

DIOPT Version :9

• Sequence 1: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Sequence 2: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 143/505 - (28%)
• Similarity: 253/505 - (50%)
• Gaps: 36/505 - (7%)

Human    24 LLILLLLLIKAVQLYLHR----------QWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKW 78
            :::|:.||:..:...|.|          |.::.::.:.|...:.|   .::..|.|....:..::
  Fly     3 VVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAW---QMRSFQPDNLHDKFAEY 64

Human    79 VETFPSACPHWLWGGKVRVQLYDPDYMKVIL-GRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQH 142
            |:.|..:....:.|..|.|.. :|.::..:| |:...|....|..|..|:|.||||..|:.|...
  Fly    65 VKRFGRSFMGTVLGHVVMVTA-EPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTM 128

Human   143 RRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGS 207
            |:::||.||:.||:.:|.:......:::::...|...:..:.::..|.|..||.|.:.|.    .
  Fly   129 RKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAM----G 189

Human   208 IQVDRN--SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSL--TSAGRWTHRACQLAHQHTDQVIQ 268
            :.||..  ....:.|:.||.|::.:|..........::.|  .|..|.........|:.|:.:|:
  Fly   190 VNVDAQGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGIIE 254

Human   269 LRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWI 333
            .|:..|.:|...:|..:...|  ||.||.|.:: |..|:||.:|.||:||:|||||||.|.:|:.
  Fly   255 QRRRLLAREANQDKPTKPHAL--LDTLLRATVD-GQPLTDKQIRDEVNTFIFEGHDTTTSAVSFC 316

Human   334 LYALATHPKHQERCREEIHSLLGDG--ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTP 396
            ||.|:.|...|::..||:....|..  ..:..:....:||.:..:||:||||||:|.:.|.|...
  Fly   317 LYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKD 381

Human   397 VTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRF----APGSAQHSHAFLPFSGGSRNC 457
            :...:| .:|.|..|::.::.|..:..::.:|.||.|.|.    ||..:.:|  ::|||.|.|||
  Fly   382 LVIDEG-YIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYS--YIPFSAGPRNC 443

Human   458 IGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLR 507
            ||::||:.|:|......:..::|||....:. |..::||:||:|:::.||
  Fly   444 IGQKFALLEMKTMVTKVIRHYQLLPMGADVE-PSIKIVLRSKSGVNVGLR 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	135/463 (29%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	134/465 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740