Protein Alignment NKX6-3 and HGTX

DIOPT Version :9

• Sequence 1: NP_001351770.1
• Gene: NKX6-3 / 157848
• HGNCID: 26328
• Length: 265
• Species: Homo sapiens
• Sequence 2: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 108/287 - (37%)
• Similarity: 134/287 - (46%)
• Gaps: 71/287 - (24%)

Human     1 MESNLQGTFLLNNTPLAQF----PEMK----------APVCQYSVQNSFYKLSPPGLGPQLA--- 48
            |:..|..:||  ..|||..    .|||          |....||...:.:.:|..|.|...:
  Fly   284 MDHKLPLSFL--GPPLAALHSMTTEMKGQGVGGSSASANGLSYSHSPNSHLISDRGSGGSSSSSS 346

Human    49 ----------AGTPHGITDILSR--PVAAPNNSLLSG-----YPHVAGFGGLS-----SQGVYYS 91
                      |..||||..|||:  ||.:...|.|:|     :...|...|::     |||....
  Fly   347 TTTTNTNSQGAPNPHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQSQGAPLK 411

Human    92 PQVGNFSKAGNEYPTRTRNCWADTGQD--------WRGGRQCSNTPD----------PLSDSIHK 138
            ...|:.       ..||...|  .|..        ||  .:.|||..          |.:|...|
  Fly   412 THAGHI-------VDRTHLYW--PGLQGLVANPIAWR--ERLSNTMSANLSQSHQHHPSNDKDGK 465

Human   139 KKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALEPS 203
            ||||||||:|.|||||||||||||||||||||:|||:|||:|||||||||||||||||:.|.| .
  Fly   466 KKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAE-M 529

Human   204 SSTPRAPGGAGAGAGGDRAPSENEDDE 230
            ::..|.....|....||.:.:.:.|:|
  Fly   530 ATAKRKQDDMGGDNDGDCSETMDSDNE 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-3	NP_001351770.1	Homeobox	142..195	CDD:306543	47/52 (90%)
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	29/105 (28%)
		Homeobox	469..523	CDD:395001	48/53 (91%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5911
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001882
OrthoInspector	1	1.000	-	-		otm42262
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24340
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4964
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.940