DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A5 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	137/530 - (25%)
Similarity:	246/530 - (46%)	Gaps:	80/530 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    12 WLLLAVSLVL-LYLYGTRTHGLFKRLGI----PGPTPLPLLGN----------VLSYRQGLWKFD 61
            |::|...|.| |:|......||.:|..:    .||:.|||:||          :|:...|.|
  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWW--- 63

Human    62 TECYKKYGK----MW-GTYEGQLPVLAITDPDVIRTVLVKECY----SVFTNRRSLGPVGFMKSA 117
                .:|||    .| |.|..    :.:|:|..:..:|..:..    .|:........:|.:.|.
  Fly    64 ----HEYGKDNFRYWIGYYSN----IMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTST 120

Human   118 ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMD 182
            .|     :|.:.|.:::|.|....|::...::.:.....:..|::.|:.|.....::.....::|
  Fly   121 GS-----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLD 180

Human   183 VITGTSFGVNIDSLNNPQDPFVESTKKF---LKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244
            ||..|:.||:|:::.|.....|::.|..   :|.....|...:..||.| .|.:...:.:|  |.
  Fly   181 VICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTL--KT 242

Human   245 TINFLSKSVNR---MKKSRL------NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300
            ..:|.::.:.:   ::||.|      ::..:.::.||..::.|:     ...:.|:..||..:..
  Fly   243 LQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-----VDGRPLTSQELYEEVS 302

Human   301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA---PPTYDAVVQMEYLDMVVNE 362
            .|:|.|::||:|.:.|.:|.|:.|||.|:||..|...|:....   ..|:..:..|::||:.:.|
  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367

Human   363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427
            ..||:|....:.|..:||..|:|..:|||:.:.:....|.::.:.:.:|.:|:||||.::|..
  Fly   368 AQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG-- 430

Human   428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC------KETQIPLKLDTQGLLQPEK 486
            |:.|.||..|||||||.:|||:.:|..:.::::||...|.      |:..|.   .|.||...||
  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYIS---TTLGLQPAEK 492

Human   487 PIVLKVDSRD 496
                  .|||
  Fly   493 ------KSRD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	125/492 (25%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	117/460 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810