Protein Alignment CYP3A5 and Cyp4c3

DIOPT Version :9

• Sequence 1: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 541
• Identity: 143/541 - (26%)
• Similarity: 253/541 - (46%)
• Gaps: 90/541 - (16%)

Human    11 TWLLLAVSLVLLYLYGTRTHGLFKRL-GIPGPTPLPLLGNVLSYRQGLWKFDTECYKK---YGKM 71
            |..||...|:.|.:|..|...|.|.: .||||..:|.|||.:.....    ..|.:.:   ..|:
  Fly    30 TVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVD----HDELFNRVIGMQKL 90

Human    72 WGT-------YEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS----LGPVGFMKSAISLAEDEE 125
            |||       ::|..|.:.:.:|:.:..:|..:   .|.|:..    |.|  ::...:..:.|.:
  Fly    91 WGTRIGINRVWQGTAPRVLLFEPETVEPILNSQ---KFVNKSHDYDYLHP--WLGEGLLTSTDRK 150

Human   126 WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAY------SMDVI 184
            |...|.:|:|.|....|.:...:..:...||.|.|..|..       .:.|..:      ::|::
  Fly   151 WHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVG-------SEAFNLFPYVTLCTLDIV 208

Human   185 TGTSFGVNIDSLNNPQDPFVES------------TKKFLKFGFLDPLFLSIILFPFLTPVFEALN 237
            ..|:.|..|.:.:|.:..:|::            .|.:|:..|:..          ||..:: |:
  Fly   209 CETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFS----------LTAEYK-LH 262

Human   238 VSLFPKDTINFLSKSVNRMKKSRL----------NDK---------QKHRLDFLQLMIDSQNSKE 283
            .|..  :|::..|..|.|.:|:.|          |:.         :|.||.||.|:||:  |||
  Fly   263 QSYI--NTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDA--SKE 323

Human   284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL--PNKAPPT 346
               ...||:.::..:...|:|.|::|||:.:|:||:.|..||:.|:::.:|:|::.  ..:.|.|
  Fly   324 ---GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPAT 385

Human   347 YDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEP 411
            ...::.|.||:..:.::|||||....:.|...:||.|.|..:|.|:..:|.|||||.:|:.:.:|
  Fly   386 MKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKP 450

Human   412 EEFRPERFSKKK-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475
            |:|.|:.|..:. ....|:.|.||..|||||||.:||::..|..:..||:.:..:.....: .|.
  Fly   451 EQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRRE-DLT 514

Human   476 LDTQGLLQPEKPIVLKVDSRD 496
            |..:.:|:|:..:.:|:..||
  Fly   515 LLGELILRPKDGLRVKITPRD 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	130/506 (26%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	130/506 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810