DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A5 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	179/538 - (33%)
Similarity:	279/538 - (51%)	Gaps:	77/538 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLLAVSLV-LLYLYGTRTHGLFKRLGIP----GPTPLPLLGNVLSYRQ----GLWKFDTECYKKY 68
            :||||:|: |.:.|..|.:..::|.|.|    ...|...|.:|  :||    ||..:|. ..|..
  Fly     5 ILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSV--WRQEKSMGLAIYDV-YVKSK 66

Human    69 GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNR-----RSLGPVGFMKSAISLAEDEEWKR 128
            .::.|.|....|.:.|.|.|:.|.||.:: ::.|.:|     ....|   :.:.|.....:.|:.
  Fly    67 ERVLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDRGVYVDEERDP---LSANIFSLRGQSWRS 127

Human   129 IRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE-AEKG-KPVTLKDIFGAYSMDVITGTSFGV 191
            :|.:|||.|||||||.||......||.:|.:|::| .|:| |.|.:|.:...|::|:|..|.||:
  Fly   128 MRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGL 192

Human   192 NIDSLNNPQDPF------VESTKKF-LKFGFLDPLFLSIILF----PFLTPVFEALNVSLFPKDT 245
            :::|..||.:.|      ..:..:| ..||.:..|..||..|    .|..||  .|.:....|:|
  Fly   193 DVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPV--GLAMLQIVKET 255

Human   246 INFLSKSVNRMKKSRLNDKQKH---RLDFLQLMIDSQNS--------------KETESH-KALSD 292
            :.:               ::||   |.|.|||:|..:|:              |..:.| |.:|.
  Fly   256 VEY---------------REKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISL 305

Human   293 LELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYL 356
            ..:.||:.||..||.|||.|..:||:||||.:|::.::||.|:|..| .|....|||::.:||:|
  Fly   306 EAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFL 370

Human   357 DMVVNETLRLFPVAIRLERTCKKDVEI---NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418
            |:.|.||:|.:|....|.|.|.:|..:   |.| ||||:.|||..|.:|||.:|:.:||.:.|||
  Fly   371 DLCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYFPDPETYDPER 434

Human   419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGL-L 482
            ||::..:.:|..:.|||.|||.||..|...:|.|||:|::||||:.:....::|  :.:..|: |
  Fly   435 FSEESRNYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI--EFENSGIAL 497

Human   483 QPEKPIVLKVDSRDGTLS 500
            .|:..:.:::..|...||
  Fly   498 IPKHGVRVRLSKRVPKLS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	166/501 (33%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	157/466 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820