Protein Alignment CYP3A5 and Cyp6d2

DIOPT Version :9

• Sequence 1: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_611698.1
• Gene: Cyp6d2 / 37594
• FlyBaseID: FBgn0034756
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 155/537 - (28%)
• Similarity: 269/537 - (50%)
• Gaps: 80/537 - (14%)

Human    12 WLLLAVSLV--LLYLYGTRTHGLFKRLGI---PGPTPLPLLGNVLSYRQGLWKFDTECYKKY-GK 70
            |.:|...|:  |||.|..|.:..::|||:   |...|..::..|:...:.|.....:.|.:: ||
  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGK 66

Human    71 MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEE---------- 125
            :.|.|......:.|.|..:.|.::..: ::.|.:|           .:.:.||::
  Fly    67 IVGIYMLNKRSILIRDAQLARQIMTSD-FASFHDR-----------GVYVDEDKDPLSANLFNLR 119

Human   126 ---WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187
               |:.:|..|:|:|:|||:|.||..|...||.||::|....::...|.:||:...|::|:|...
  Fly   120 GASWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSV 184

Human   188 SFGVNIDSLNNPQDPFVE---STKK----FLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT 245
            .||:.|||..||::.|.|   ||.:    .||..     .:|:.:.|   |:.:.:|       .
  Fly   185 IFGLEIDSFRNPKNEFREISSSTSRDESLLLKIH-----NMSMFICP---PIAKLMN-------R 234

Human   246 INFLSK---SVNRMKKSRLNDKQKH---RLDFLQLMIDSQNS------------KET--ESHKAL 290
            :.:.|:   |:..|.|..:..:::|   |.|.|||:|..:|:            .||  |..|::
  Fly   235 LGYESRILTSLRDMMKRTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSM 299

Human   291 SDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL--PNKAPP---TYDAV 350
            |..::|||:.:|..||.|:|::..:||||||:.:|::.::.|:|:||||  .|..|.   ||:||
  Fly   300 SIEKIAAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAV 364

Human   351 VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGV--FIPKGSMVVIPTYALHHDPKYWTEPEE 413
            ..:::||:.:.||:|.:|....|.|.|.:|..:.|.  .|.||:.::|..:.:..||.|:..|..
  Fly   365 QDLKFLDICIMETIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNG 429

Human   414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 478
            :.|.||.....:.|...|.|||.|||:||.:|...:|.|:|:.::|.||........::..:.|.
  Fly   430 YDPHRFDSNNMNYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDA 494

Human   479 QGLLQPEKPIVLKVDSR 495
            ..:|..::|:.|::..|
  Fly   495 APVLVTKEPLKLRLTKR 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	143/500 (29%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	137/467 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820