DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A5 and Cyp6a20

DIOPT Version :9

Sequence 1:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens
Sequence 2:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	166/537 - (30%)
Similarity:	271/537 - (50%)	Gaps:	90/537 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     7 LAVETWLLLAV-SLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKK-YG 69
            :||...||:.| :.|..|::  :....:||.|||...|....||.....:.:...|  .:|: |.
  Fly     1 MAVMIVLLIGVITFVAWYVH--QHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFAD--IFKRTYN 61

Human    70 KMWGTYEGQL--------PVLAITDPDVIRTVLVKEC-----YSVFTNRRSLGPVGFMKSAISLA 121
            |:....:|..        .::.:||.|..:|||::|.     ..||.|.|. .|   :.:.:...
  Fly    62 KLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERD-DP---LSANLVNI 122

Human   122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAE-KGKPVTLKDIFGAYSMDVIT 185
            :.::||.:|..|:|||||||:|.|||.|...||.|:|.....|. ....:.:.::...::.|||.
  Fly   123 DGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIG 187

Human   186 GTSFGVNIDSLNNPQDPFVE------------STKKFLKFGF---------------LDPLFLSI 223
            ..:||::..||::|:..||:            .:...|.||.               ::..:::|
  Fly   188 SCAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGAPELAAKLRMKATVQEVEDFYMNI 252

Human   224 ILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKET-ESH 287
            |                  :||:::      |:|    |:.::|  ||:.::|:.:...:. :..
  Fly   253 I------------------RDTVDY------RVK----NNVKRH--DFVDMLIEMKLKFDNGDKE 287

Human   288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVV 351
            ..|:..|:|||:.||..||:||:|:.:.|.|||||.|.|:|.||:.||:.|| .:.....||::.
  Fly   288 NGLTFNEIAAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMR 352

Human   352 QMEYLDMVVNETLRLFPVAIRLERTCKKDVE-INGVF-IPKGSMVVIPTYALHHDPKYWTEPEEF 414
            :|.||:.|::||:|..||...|.|...:..: .|..: |.||:.|::||.|:||||:::.|||:|
  Fly   353 EMTYLEKVIDETMRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKF 417

Human   415 RPERFSKKKDSIDP-YIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK--PCKETQIPLKL 476
            .||||.:.:....| ..:.|||.|||||||:||..|.:.:.:..::.||.|:  |.| |.:||:.
  Fly   418 IPERFDEDQVQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTK-TVVPLEY 481

Human   477 DTQG-LLQPEKPIVLKV 492
            .|.. ||..:..|.|||
  Fly   482 RTDDFLLSSKGGIHLKV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	153/502 (30%)
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	152/500 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720