DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A5 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	168/519 - (32%)
Similarity:	266/519 - (51%)	Gaps:	60/519 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLLAVSLVL---LYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYR-----QGLWKFDTECYKKY- 68
            :|||:.:||   |.|...|....::.|.||...|..|:|::...:     ..:|   .:.|.|:
  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIW---MDYYNKFR 67

Human    69 --GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGF--------MKSAISLAED 123
              |...|.|..|.|.:.:.|..:.:.:|:|| ::.||:|      ||        :...:.|.:.
  Fly    68 GTGPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDR------GFYHNTEDDPLSGQLFLLDG 125

Human   124 EEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTS 188
            ::||.:||.||.||||||:|.|||.:.:.|...:....:..||...|.::||...::.|||...:
  Fly   126 QKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCA 190

Human   189 FGVNIDSLNNPQDPFVESTKKFL---KFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLS 250
            ||:...||.:|:..|....::.:   :.|.:...|::         .|:.|...|..|.|:....
  Fly   191 FGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFIN---------SFQNLARRLHMKITLEEAE 246

Human   251 KSVNRMKKSRLNDKQKH---RLDFLQLMIDSQNSKETESHKA----LSDLELAAQSIIFIFAGYE 308
            ....|:.:..:..::|:   |.||:..:||.:||..|:|...    |:..|:|||:.:|..||:|
  Fly   247 HFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFE 311

Human   309 TTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETLRLFPVAIR 372
            |:|:.:.|.|||||.|.|:|.:::||...|:.. ....||:::..|.|||.|::|||||:.|...
  Fly   312 TSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPV 376

Human   373 LERTCKKDVEING---VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS----KKKDSIDPYI 430
            |.|.|.:|.|:.|   ..|.||..|:||..|:|.|.|.:..|..|.|:.||    |::||::
  Fly   377 LNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVE--- 438

Human   431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG-LLQPEKPIVLKVD 493
            :.|||.||||||||||..|..:..|..::..|.|..|::|.||:....:. |:..|..|.|||:
  Fly   439 WLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	156/487 (32%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	155/485 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720