DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A5 and Cyp6a19

DIOPT Version :9

Sequence 1:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens
Sequence 2:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	163/514 - (31%)
Similarity:	263/514 - (51%)	Gaps:	60/514 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWK------ 59
            |.::..|.|....|:|..::..|.|       :||.|||...|...|||.    ..||:
  Fly     1 MAILLGLVVGVLTLVAWWVLQNYTY-------WKRRGIPHDPPNIPLGNT----GELWRTMPLAG 54

Human    60 FDTECYKKY-----GKMWGTYEGQLPVLAITDPDVIRTVLVKEC-----YSVFTNRRSLGPVGFM 114
            .....|.|:     |...|.|...:..:.|||.|.::|||:::.     ..|:.|.:. .|   :
  Fly    55 ILKRTYLKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKD-DP---L 115

Human   115 KSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL-RREAEKGKPVTLKDIFGA 178
            .:.::..|.::||.:|..|:.||||.|:|.||..:...||.::|.: .:.:...:.:.:.||...
  Fly   116 TNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSR 180

Human   179 YSMDVITGTSFGVNIDSLNNPQDPFVE---STKKFLKFGFLDPLF------LSIIL-FPFLTPVF 233
            ::.|||...:||:..:||.:|:..||:   |..:..:.|:|..|.      |::.| |.||.|..
  Fly   181 FTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSV 245

Human   234 EALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMID-SQNSKETESHKALSDLELAA 297
            :...:.:. :|||::      |||      ::..|.||:..:|| .|...:.:....|:..|:||
  Fly   246 QKFYMKIV-QDTIDY------RMK------RKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAA 297

Human   298 QSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVN 361
            |:.:|..||:|..|:.:.|||||||.:.|||.||:.|||:||.. .....||::..:.|::.|:|
  Fly   298 QAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVIN 362

Human   362 ETLRLFPVAIRLERTCKKDVEING--VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD 424
            |:||..||...|.|...|..:.:.  .||..|:.|::.|..:||||:::.|||:|.||||.:::.
  Fly   363 ESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQV 427

Human   425 SIDP-YIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLL 482
            ...| ..:.|||.|||||||:||..|.:.:.|..::.||.|:...:|.:|:|.....||
  Fly   428 KKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	152/476 (32%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	152/476 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720