Protein Alignment CYP3A5 and Cyp6t3

DIOPT Version :9

• Sequence 1: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_610745.1
• Gene: Cyp6t3 / 36318
• FlyBaseID: FBgn0033697
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 512
• Identity: 145/512 - (28%)
• Similarity: 236/512 - (46%)
• Gaps: 53/512 - (10%)

Human    12 WLLLAVSLVLLYLYGTRTHGLFKRLGIP-----GPTPLPLLGNVLSYRQGLWKFDTECY----KK 67
            |||| :::|.|..:....:..|:..|||     ..:|:..||.:|..|........:.|    ..
  Fly     5 WLLL-LTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPRNG 68

Human    68 YGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAIS--LAEDEEWKRIR 130
            ..|:.|.:..|.|.|.:.||::||.||:|. ::.|.||......|....|::  ||:...||..|
  Fly    69 QAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGALTLPLAKYHHWKESR 132

Human   131 SLLSPTFTSGKLK-----EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFG 190
            ..:|..||||:::     :|..:.:.....|.|.|....|:..|  |..:...|:.||.....:.
  Fly   133 QCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLP--LGRMCQLYTTDVTGNLFYS 195

Human   191 VNIDSLNNPQDPFVESTKKFLKFG---FLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKS 252
            :|:..|...:...:..||:.....   .||  |:|:...|..|.|   |...:|.:|...::...
  Fly   196 LNVGGLRRGRSELITKTKELFNTNPRKVLD--FMSVFFLPKWTGV---LKPKVFTEDYARYMRHL 255

Human   253 VN----RMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSV 313
            |:    ..|...:|..|..:|        |::|.....|...    :|:|:.|.:.||:||:|::
  Fly   256 VDDHHEPTKGDLINQLQHFQL--------SRSSNHYSQHPDF----VASQAGIILLAGFETSSAL 308

Human   314 LSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCK 378
            :.|||||||..||:|::|:.|:.....:.|..:||.::.:.||.||..|.|||:|.|..:.|.|.
  Fly   309 MGFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECT 373

Human   379 KDVEIN-------GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD-SIDPYIYTPFG 435
            ......       ...:|.|....|....||.|.::|.||..|.||||..::. .|.|..|.|||
  Fly   374 SSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFG 438

Human   436 TGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG-LLQPEKPIVLK 491
            .||..|||.|..::.:||.::.:|:.:..:.|:.|...::.:.:. :|:.|..|.|:
  Fly   439 AGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	136/485 (28%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	131/471 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820