Protein Alignment CYP3A5 and Cyp4ad1

DIOPT Version :9

• Sequence 1: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Alignment Length: 562
• Identity: 133/562 - (23%)
• Similarity: 236/562 - (41%)
• Gaps: 128/562 - (22%)

Human    14 LLAVSLVL---LYLYGTRTHGLFKRLG-----IPGPTPLPLLGN--------------VLSYRQG 56
            |:|::::|   |...|.|.......:.     ||||||.|.:||              ||.|.:
  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCR- 66

Human    57 LWKFDTECYK-----KYGKMWGTYEGQLPVLAITDPDVIRTV------LVKE-CYSVFTNRRSLG 109
              |:|.:.::     :|..|            ::||..|:.:      |.|| .||..  |..||
  Fly    67 --KYDFQGFRSLVFLQYHMM------------LSDPAEIQNILSSSSLLYKEHLYSFL--RPWLG 115

Human   110 PVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKD 174
            . |.:.|:     ...|.:.:.|.:|.|....::....::.:.|...|:.|...::..:....::
  Fly   116 D-GLLTSS-----GARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQE 174

Human   175 IFGAYSMDVITGTSFGVNIDSLNNPQ-----------DPFVESTKKFLKFGFLDPLFLSIILFPF 228
            :....::|::...:.|.:..|||...           |...|.|...:|  ..|.||.
  Fly   175 LVAKCTLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQERTFSIVK--RFDALFR------- 230

Human   229 LTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRL--------------DFLQLMIDSQ 279
            ||..:      :..:..::.|...:||:...|     :|:|              .||.:::.::
  Fly   231 LTSYY------MKQRRALSLLRSELNRIISQR-----RHQLAAENTCQQGQPINKPFLDVLLTAK 284

Human   280 NSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344
                 ...|.|.:.|:..:...|||.|::..::.:|||||.|:.|.::|||..:|...:......
  Fly   285 -----LDGKVLKEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFA 344

Human   345 PTYD--AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407
            ...|  .:.||.||::::.|||||:|....:.||.:..::|||..:.|.:.|::...|:.::.||
  Fly   345 GEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKY 409

Human   408 WTEPEEFRPERFSKKKDS--IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC--- 467
            :.:|..||||||.....:  |:.:...||..|||.||..:||:..||..|.::|:.|...|.
  Fly   410 FDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDG 474

Human   468 ---------KETQIPLK-----LDTQGLLQPEKPIVLKVDSR 495
                     :|..:|..     |:.:..|:.|..|.:::..|
  Fly   475 LPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQIRLRKR 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	125/524 (24%)
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	118/481 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810