Protein Alignment CYP3A5 and Cyp4ac3

DIOPT Version :10

• Sequence 1: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_608918.1
• Gene: Cyp4ac3 / 33756
• FlyBaseID: FBgn0031695
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 128/494 - (25%)
• Similarity: 231/494 - (46%)
• Gaps: 72/494 - (14%)

Human    38 IPGPT----PLPLL----GNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTV 93
            :||.|    .|.||    .|:.|| |:...|.:.:.|     :|.       .|...:.:::|..
  Fly    50 VPGKTRFGNNLDLLNLTPANIFSYIRESTAKANGQNY-----IWN-------FLFAPEYNIVRAE 102

Human    94 LVKECY---SVFTNRRS---LGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQY 152
            ..:|.:   .:.|...|   :.|  |:...:.::.|::|...|..|:|.|....|:....|..:.
  Fly   103 DAEEIFQSTKITTKNMSYELIRP--FLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEE 165

Human   153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFL- 216
            ....::.|.:..  |..:.|..|...::::.|..|:.||.:|.::...    |..|....|..:
  Fly   166 SKKFIKILDKNV--GFELELNQIIPQFTLNNICETALGVKLDDMSEGN----EYRKAIHDFEIVF 224

Human   217 -----DPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL---- 272
                 :||......| ||...::..:..|   .||:..|..:.:.|:.:...||..::|..
  Fly   225 NQRMCNPLMFFNWYF-FLFGDYKKYSRIL---RTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQ 285

Human   273 -QLMIDSQNSKETE---SHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 333
             ..|:|:..:.|.|   .|:.:.|     :...|:|.||:|||:.|.|||..||.|.|||::..:
  Fly   286 RYAMLDTLLAAEAEGKIDHQGICD-----EVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYE 345

Human   334 EIDAVLPNKAPPTYDAVVQMEY-----LDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSM 393
            |:..:     |...|.|...::     |:.|:.|:|||||.|..:.|||.::..:||:.:||.:.
  Fly   346 ELQDL-----PEDIDEVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQ 405

Human   394 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID--PYIYTPFGTGPRNCIGMRFALMNMKLALI 456
            :.|..|.:..|.:::.:|.:|.|||| ..::|::  |:.:.||..|||||||.:|.::.:|:.|.
  Fly   406 ISIHIYDIMRDARHFPKPNQFLPERF-LPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLA 469

Human   457 RVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495
            .|::||...|..:.: .|..:...:|:.::.|.:|.::|
  Fly   470 AVIRNFKLLPATQLE-DLTFENGIVLRTQQNIKVKFEAR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	114/450 (25%)
Cyp4ac3	NP_608918.1	CYP4	87..502	CDD:410721	114/445 (26%)