Protein Alignment CYP3A5 and Cyp28d1

DIOPT Version :10

• Sequence 1: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_608912.1
• Gene: Cyp28d1 / 33749
• FlyBaseID: FBgn0031689
• Length: 502
• Species: Drosophila melanogaster
• Alignment Length: 492
• Identity: 141/492 - (28%)
• Similarity: 247/492 - (50%)
• Gaps: 47/492 - (9%)

Human    14 LLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSY----RQGLWKFDT--ECYKKYGKMW 72
            ::|..|.|:|::.|.....:|:.|||.....|.:|:..|.    |..::..|.  |.||....:.
  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIV 74

Human    73 GTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAED------EEWKRIRS 131
            |.::.::|.|.:|.|:....:.|.:..|...|  .:......|:...||.:      |.||..|:
  Fly    75 GVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDN--EMAKFTDSKTDPILANNPFVLTGEAWKERRA 137

Human   132 LLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREA--EKGKPVTLKDIFGAYSMDVITGTSFGVNID 194
            .::|..::.::|..:|:..:.....|..:||::  ...:.:..||:...|:.:||:....|::..
  Fly   138 EVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGISAQ 202

Human   195 SLNNPQDPFVESTKKFLK--FGFLDPLFLSII--LFPFLTPVFEALNVSLFPKDTINFLSKSVNR 255
            |..:...|.|..||:..:  |||   :|.:::  |:|   |:.:..:||||.||...|....:.:
  Fly   203 SFTDNPTPMVGMTKRVFEQSFGF---IFYTVVANLWP---PITKFYSVSLFAKDVAAFFYDLMQK 261

Human   256 -MKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 319
             ::..|.:...:.|.|||..|:..|..      |.|:..||.:.::.|:..|:|||:.||:.||.
  Fly   262 CIQVRRESPAAQQRDDFLNYMLQLQEK------KGLNAAELTSHTMTFLTDGFETTAQVLTHTLL 320

Human   320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI- 383
            .||.:|..|.||::||     ..|..|::.:.::.:.:..::||||:|...:...:...:..|:
  Fly   321 FLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELT 380

Human   384 --NGVFIP--KGSMVVIPTYALHHDPKYWTEPEEFRPERF----SKKKDSIDPYIYTPFGTGPRN 440
              |||.:.  .|.:|:||..||||||:|:.||:.|:||||    ...|...|..::..||.|||.
  Fly   381 NKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRI 445

Human   441 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD 477
            |.||||:|..:|.||:.:::||..|...:|:...::|
  Fly   446 CPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEID 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	124/433 (29%)
Cyp28d1	NP_608912.1	CYP6-like	69..495	CDD:410679	124/433 (29%)