DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A5 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	136/497 - (27%)
Similarity:	236/497 - (47%)	Gaps:	66/497 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     7 LAVETWLLLAVSL-----VLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQG-LWKFDTECY 65
            ||:..::|.|..|     :|.:|   |.....|.|  ||||...|:.||   ::| :..:..|..
  Fly     4 LALVAFVLWAAFLRYLPKILNFL---RLQRFAKTL--PGPTIGELIANV---KKGEILNWLKELR 60

Human    66 KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS---LGPVGFMKSAISLAEDEEWK 127
            :|:|.::..:.|:..::..|||:.|:.:|...  .:.|..|:   |.|  ::...:.....|.|.
  Fly    61 EKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEP--WLGKGLLTNGGESWH 121

Human   128 RIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVN 192
            |.|.||:|.|....|.|....:.:...:|||.||.:| .|:...:......:::|.|..|:.|:.
  Fly   122 RRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKA-NGESFDIYPYITLFALDAICETAMGIK 185

Human   193 IDSLNNPQDPFVESTKKFLK------FGFLDPLFLSIILFPFLTPVFE---ALNVSLFPKDTINF 248
            ..:.......:|::.:...:      |.|...|   .:.|....|..|   ||.|       ::.
  Fly   186 KHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRL---NVFFKHTKPGKEREAALKV-------LHD 240

Human   249 LSKSVNRMKKSRLNDKQ--------------KHRLDFLQLMIDSQNSKETESHKALSDLELAAQS 299
            .:..|.|:::.:|..::              |.||.||.:::.:|    .|....|||.::..:.
  Fly   241 ETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQ----MEGGAELSDTDIREEV 301

Human   300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364
            ..|:|.|::||||.::|.|..|:.:|||||:..:|...:...:..       .|.||:.|:.|||
  Fly   302 DTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREKE-------SMPYLEAVIKETL 359

Human   365 RLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429
            |::|......|...:|:|:..:.:|||:.:....|.||.|||.:.:||.|.|:||...:..:.|:
  Fly   360 RIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPF 424

Human   430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 471
            .:..|..|||||||.:||::.:|.:|..:|:::.|.|.|:.|
  Fly   425 AFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	126/460 (27%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	127/463 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810