DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A5 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	132/494 - (26%)
Similarity:	230/494 - (46%)	Gaps:	47/494 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLLAVSLVL--LYLYGTRTHGLFKRLGIPGPTPLPLLG---NVLSYRQGLWKFDTECYKKYGKMW 72
            |||.::.:|  :|.:.....|.::|.|:..|..|||.|   |::..||.......:.|..|....
  Fly     5 LLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRNTH 69

Human    73 ---GTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAI-----SLAEDEEWKRI 129
               |.|..:.|.|.:.:|.::..:.| ..:|.|.|..:...|...|..:     .:.|.|||:..
  Fly    70 SYVGCYLLRAPKLLVLEPRLVYEIYV-SAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWRHQ 133

Human   130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNID 194
            |::.|...|:|:::....|:.:....|.:.:..::..||.:...|:...::.:.:.....|:...
  Fly   134 RAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGIQAR 198

Human   195 SLNNPQDPFVESTKKFLKFGFLDPLFLSII-----LFPFLTPVFEALNVSLFPKDTINFLSKSVN 254
            :..:...|.|....:.    ..:...|:|.     |||.|.   ..|...:||:....|..:.::
  Fly   199 TFTDNPLPVVRQNHEM----SAENRGLAIAGAVHGLFPNLP---RWLRPKVFPRSHDRFYGQMIS 256

Human   255 ---RMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 316
               |:::|    |.:.|.||:..:::.|...:      ||:.::|:.::.|:|.|.:|||:.::.
  Fly   257 EALRLRRS----KHQERNDFINHLLEMQRELD------LSEEDMASHAMTFMFDGLDTTSNSIAH 311

Human   317 TLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV 381
            .|..|..:||.|::|.:|:..|.|....|..||::.:.||....||:||::|......:||.|:.
  Fly   312 CLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEY 376

Human   382 EING------VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF--SKKKDSIDPYIYTPFGTGP 438
            |:.|      :.:..|..|::|.||||:||..:.||:.||||||  ...|:.....|:..||.||
  Fly   377 ELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGP 441

Human   439 RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD 477
            |.|:|||..|...|.||..::|.|.......|....:||
  Fly   442 RQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELD 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	124/466 (27%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	124/464 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820