DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A5 and Cyp4ae1

DIOPT Version :9

Sequence 1:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens
Sequence 2:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	149/537 - (27%)
Similarity:	245/537 - (45%)	Gaps:	96/537 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    14 LLAVSLVLLYLYGTRTHGLFKRLG-----------IPGPTPLPLLGNVLSYR----QGLWKFDTE 63
            :|.|.||.|.:  ||......||.           :|..:.:||||.....|    ..|.....|
  Fly     1 MLVVLLVALLV--TRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFAE 63

Human    64 CYKKYGKMW-GTYEGQLPVLAITDPDVIRTVL-----VKECYSVFTNRRSLGPVGFMKSAISLAE 122
            ..|::|:.: ||..|.: |:...:|..|..:|     :|:....|..|      |::...:.|:.
  Fly    64 YVKRFGRSFMGTVLGHV-VMVTAEPRHIDALLQGQHQLKKGTMYFALR------GWLGDGLLLSR 121

Human   123 DEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187
            .:||..:|.:::|||....|::...:..:...:||..||..:...:.|.:..:.|..::|:||.|
  Fly   122 GKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITET 186

Human   188 SFGVNIDSLNNPQDPF--VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT--INF 248
            :.|||:|:.....:..  |:.....|...|:.|    .:|||.|   |.....|.|.|..  :..
  Fly   187 AMGVNVDAQGADSEVVHAVKDLTNILATRFMRP----HLLFPHL---FRLCWPSGFRKQQAGVIC 244

Human   249 LSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESH-------------KALSDLELAAQSI 300
            |.:..|.:      .:|:.||    |..::...|.|:.|             :.|:|.::..:..
  Fly   245 LHEFTNGI------IEQRRRL----LAREANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVN 299

Human   301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI----------DAVLPNKAPPTYDAVVQMEY 355
            .|||.|::||:|.:||.||.|:.|..|||||.:|:          ..:|.:.|        .:.|
  Fly   300 TFIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFA--------TLPY 356

Human   356 LDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER-F 419
            |..||.|:|||:|....:.|..:||:.|:..:||.|:.||:..:.|..|...:|:|..|:||| .
  Fly   357 LSCVVKESLRLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHL 421

Human   420 SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQP 484
            .::...:.||.|.||..|||||||.:|||:.||..:.:|::::..       :|:..|    ::|
  Fly   422 GEEAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQL-------LPMGAD----VEP 475

Human   485 EKPIVLKVDSRDGTLSG 501
            ...|||:  |:.|...|
  Fly   476 SIKIVLR--SKSGVNVG 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	137/490 (28%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	138/495 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910