DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A5 and Cyp4d2

DIOPT Version :9

Sequence 1:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens
Sequence 2:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	485	Identity:	149/485 - (30%)
Similarity:	250/485 - (51%)	Gaps:	50/485 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLLAVSLVLL--YLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYR----QGLWKFDTECYKKYGKM 71
            ||:|.:.:||  :|:..|.:|:     :|||.|||.|||:|.||    :.:..|..:..:|||::
  Fly     9 LLVAFATLLLWDFLWRRRGNGI-----LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRL 68

Human    72 WGTY-EGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSP 135
            :..: ..||.|.: |||..|..||..:.:....|...|... ::...:.::...:|...|.:::|
  Fly    69 YRVWILHQLAVFS-TDPRDIEFVLSSQQHITKNNLYKLLNC-WLGDGLLMSTGRKWHGRRKIITP 131

Human   136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200
            ||....|::...|..|...|:|..|:..|:...|:.:..:....::|:|..|:.|..|::..||.
  Fly   132 TFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPN 196

Human   201 DPFVEST--------KKFL-KFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRM 256
            .|:|::.        |:|: .:..:|.:|.       ||...||.......|...:|....:...
  Fly   197 LPYVQAVNDVTNILIKRFIHAWQRVDWIFR-------LTQPTEAKRQDKAIKVMHDFTENIIRER 254

Human   257 KKSRLNDK-------------QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYE 308
            :::.:|:.             ||.|:..|.:::.|     |.....|||.::..:...|:|.|::
  Fly   255 RETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQS-----TIDGAPLSDEDIREEVDTFMFEGHD 314

Human   309 TTSSVLSFTLYELATHPDVQQKLQKEIDAVL--PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI 371
            ||:|.:||.|||::.||:|||:||:||..||  ..|:|.|...:.::::::.|:.|:|||.|...
  Fly   315 TTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVP 379

Human   372 RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGT 436
            .:.|...:||||.|..||.|:...:..:.|..||:|:..|:|||||||......|.||.|.||..
  Fly   380 MIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSA 444

Human   437 GPRNCIGMRFALMNMKLALIRVLQNFSFKP 466
            |||||||.:||::.||..:.::|::|...|
  Fly   445 GPRNCIGQKFAMLEMKSTVSKLLRHFELLP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	141/457 (31%)
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	141/457 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810