DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A4 and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	159/509 - (31%)
Similarity:	258/509 - (50%)	Gaps:	51/509 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    14 LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPF-LGNILSYHKGFCMFDM-----ECHKKYGKVW 72
            ||.::|.:.:.:....:..:.:.|| |..|..| :||:..:.|.....|:     |..|..|..:
  Fly     7 LLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGAPF 70

Human    73 -GFYDGQQPVLAITDPDMIKTVLVK-----ECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS 131
             ||:...:||:.:||.::.|.:|::     |...::.|.|.....|.:..    .:..:|:.||.
  Fly    71 AGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR----IDGPKWRPLRQ 131

Human   132 LLSPTFTSGKLKEMVPIIAQYGDVLVR---NLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNI 193
            .:||||||.|:|.|.|.:.:.|:.|.:   .|...|..| .:.:.|:...|:.|||...:|||..
  Fly   132 KMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCG-ILEIGDLMARYTSDVIGRCAFGVEC 195

Human   194 DSLNNPQDPFVENTKKLL----RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF----LR 250
            :.|.||:..|....::..    ....:|.|   |..||.:...|.:..|   .:::|:|    :|
  Fly   196 NGLRNPEAEFAIMGRRAFSERRHCKLVDGF---IESFPEVARFLRMRQI---HQDITDFYVGIVR 254

Human   251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315
            ::||:.:|..:.     |.||:.|:|:.:...|      |:..|:.||:.||..||::|::|.|.
  Fly   255 ETVKQREEQGIV-----RSDFMNLLIEMKQRGE------LTIEEMAAQAFIFFAAGFDTSASTLG 308

Human   316 FIMYELATHPDVQQKLQEEIDAVLP-NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKK 379
            |.:||||..|.:|.||:||||..|. :....|||::.::.|:::|:.||||.:||..:|.|:.:.
  Fly   309 FALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRH 373

Human   380 DVEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441
            .....|   .:|..|.:::||.|.:|.||..:.||.||:||||............:.|||.||||
  Fly   374 LYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRN 438

Human   442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK-LSLGGLLQPEKPVVLKVE 494
            ||||||..|...:.|:.:|:||.|..|..|...:: |....||.|...:.|||:
  Fly   439 CIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKVQ 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	152/481 (32%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	151/477 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920