Protein Alignment CYP3A4 and Cyp6a17

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_652018.1
• Gene: Cyp6a17 / 45556
• FlyBaseID: FBgn0015714
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 176/508 - (34%)
• Similarity: 276/508 - (54%)
• Gaps: 38/508 - (7%)

Human    13 LLLAVSLVLLYLY---GTHSHGLFKKLGIPGPTPLPFLGNILSY--HKGFCMFDMECHKKYGK-- 70
            ||||:.:|:|.|.   ....||.:::.|||.....|..|||..:  .:.......:.:.||..
  Fly     2 LLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSD 66

Human    71 --VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKSAISIAEDEEWKR 128
              ..||:........:||.:::|.||:|: ::.|.||..|     .|   :.:.:...|.::|:.
  Fly    67 YPFAGFFFFFTRTAVVTDMELLKRVLIKD-FNHFENRGVFYNEIDDP---LSATLFSIEGQKWRH 127

Human   129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE--AETGKPVTLKDVFGAYSMDVITSTSFGV 191
            ||..|:|||||||:|.|.||:.:.|:.:.:..|.:  |:.|:.:.:.|:...|:.|||.:.:||:
  Fly   128 LRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGL 192

Human   192 NIDSLNNPQDPFVENTKKLL---RF-DFLDPFFLSITVFPFLIPILEV-LNICVFPREVTNFLRK 251
            |.:||.:|:..||...|:.:   |: :.||.|...   ||.|...|.: |||    :|..:|..|
  Fly   193 NCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFG---FPKLSRRLRLKLNI----QEAEDFYTK 250

Human   252 SVKRMKESRLEDTQKHRVDFLQLMIDS-QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315
            .|:...:.||. |::.|.||:..:|:. :|.:...|...|:..||:||:.||..||:||:|:.:.
  Fly   251 IVRETIDYRLR-TKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMG 314

Human   316 FIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKK 379
            |.:||||.:.|||.||:|||..|. .:....||:.:.:|:||:.||.||||.:|:...|.|:...
  Fly   315 FALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDT 379

Human   380 DV--EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442
            |.  |....||.||.:|:||:..:|.||..:.|||.|.||||:.:.........:.|||.|||||
  Fly   380 DFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRNC 444

Human   443 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG-LLQPEKPVVLKVE 494
            ||:||.:|...:.|..:::.:.|....|||||:|:.:.. |:..|..:.||||
  Fly   445 IGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKVE 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	156/445 (35%)
Cyp6a17	NP_652018.1	CYP6-like	66..493	CDD:410679	154/438 (35%)