DRSC/TRiP Functional Genomics Resources

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Protein Alignment CYP3A4 and Cyp6a17

DIOPT Version :9

Sequence 1:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens
Sequence 2:NP_001286433.1 Gene:Cyp6a17 / 45556 FlyBaseID:FBgn0015714 Length:501 Species:Drosophila melanogaster


Alignment Length:508 Identity:176/508 - (34%)
Similarity:276/508 - (54%) Gaps:38/508 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    13 LLLAVSLVLLYLY---GTHSHGLFKKLGIPGPTPLPFLGNILSY--HKGFCMFDMECHKKYGK-- 70
            ||||:.:|:|.|.   ....||.:::.|||.....|..|||..:  .:.......:.:.||..  
  Fly     2 LLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSD 66

Human    71 --VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKSAISIAEDEEWKR 128
              ..||:........:||.:::|.||:|: ::.|.||..|     .|   :.:.:...|.::|:.
  Fly    67 YPFAGFFFFFTRTAVVTDMELLKRVLIKD-FNHFENRGVFYNEIDDP---LSATLFSIEGQKWRH 127

Human   129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE--AETGKPVTLKDVFGAYSMDVITSTSFGV 191
            ||..|:|||||||:|.|.||:.:.|:.:.:..|.:  |:.|:.:.:.|:...|:.|||.:.:||:
  Fly   128 LRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGL 192

Human   192 NIDSLNNPQDPFVENTKKLL---RF-DFLDPFFLSITVFPFLIPILEV-LNICVFPREVTNFLRK 251
            |.:||.:|:..||...|:.:   |: :.||.|...   ||.|...|.: |||    :|..:|..|
  Fly   193 NCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFG---FPKLSRRLRLKLNI----QEAEDFYTK 250

Human   252 SVKRMKESRLEDTQKHRVDFLQLMIDS-QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315
            .|:...:.||. |::.|.||:..:|:. :|.:...|...|:..||:||:.||..||:||:|:.:.
  Fly   251 IVRETIDYRLR-TKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMG 314

Human   316 FIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKK 379
            |.:||||.:.|||.||:|||..|. .:....||:.:.:|:||:.||.||||.:|:...|.|:...
  Fly   315 FALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDT 379

Human   380 DV--EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442
            |.  |....||.||.:|:||:..:|.||..:.|||.|.||||:.:.........:.|||.|||||
  Fly   380 DFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRNC 444

Human   443 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG-LLQPEKPVVLKVE 494
            ||:||.:|...:.|..:::.:.|....|||||:|:.:.. |:..|..:.||||
  Fly   445 IGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKVE 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYP3A4NP_059488.2 p450 39..493 CDD:365848 162/476 (34%)
Cyp6a17NP_001286433.1 p450 36..478 CDD:278495 157/453 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 1 1.000 - - FOG0000037
OrthoInspector 1 1.000 - - mtm8447
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.820

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