Protein Alignment CYP3A4 and Cyp4e1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 529
• Identity: 135/529 - (25%)
• Similarity: 249/529 - (47%)
• Gaps: 77/529 - (14%)

Human    12 WLLLAVSLVL-LYLYGTHSHGLFKKLGI----PGPTPLPFLGN----------ILSYHKGFCMFD 61
            |::|...|.| |:|......||.::..:    .||:.||.:||          ||:...|:
  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGW---- 62

Human    62 MECHKKYGK----VW-GFYDGQQPVLAITDPDMIKTVLVKECY----SVFTNRRPFGPVGFMKSA 117
               ..:|||    .| |:|..    :.:|:|..::.:|..:..    .|:....|:..:|.:.|.
  Fly    63 ---WHEYGKDNFRYWIGYYSN----IMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTST 120

Human   118 ISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMD 182
            .|     :|.:.|.:::|.|....|::...::.:.....:..|::.|:.|.....::.....::|
  Fly   121 GS-----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLD 180

Human   183 VITSTSFGVNIDSLNNPQDPFVENTKKL---LRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244
            ||..|:.||:|:::.|.....|:..|.:   ::.....|:..:..:|.|.....|........::
  Fly   181 VICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQD 245

Human   245 VTNFLRKSVKRMKESRLE------DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFI 303
            .||.:......:::|.||      :..:.::.||..::.|:     ...:.|:..||..:...|:
  Fly   246 FTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-----VDGRPLTSQELYEEVSTFM 305

Human   304 FAGYETTSSVLSFIMYELATHPDVQQKL-QEEIDAV----LPNKAPPTYDTVLQMEYLDMVVNET 363
            |.|::||:|.:.|.:|.|:.|||.|:|| .|:.|.:    |...|  |:..:..|::||:.:.|.
  Fly   306 FEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDA--TFQEISTMKHLDLFIKEA 368

Human   364 LRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
            .||:|....:.|..:||..|:|..:|||..:.:....|..:.:.:.:|.||.||||   :::...
  Fly   369 QRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERF---DREKPG 430

Human   429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP----LKLSLGGLLQP-EKP 488
            |:.|.||.:|||||||.:|||:.:|..:.::::||...|..:..:.    :..:||  ||| ||
  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLG--LQPAEK- 492

Human   489 VVLKVESRD 497
                 :|||
  Fly   493 -----KSRD 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	115/452 (25%)
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	116/456 (25%)