Protein Alignment CYP3A4 and Cyp4c3

DIOPT Version :9

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 532
• Identity: 140/532 - (26%)
• Similarity: 249/532 - (46%)
• Gaps: 71/532 - (13%)

Human    11 TWLLLAVSLVLLYLYGTHSHGLFKKL-GIPGPTPLPFLGNILSYHKGFCMFDMECHKKYG--KVW 72
            |..||...|:.|.:|......|.|.: .||||..:|||||.:..:..   .|...::..|  |:|
  Fly    30 TVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVD---HDELFNRVIGMQKLW 91

Human    73 G-------FYDGQQPVLAITDPDMIKTVLVKECYSVFTNR-------RPFGPVGFMKSAISIAED 123
            |       .:.|..|.:.:.:|:.::.:|..:   .|.|:       .|:...|.:.|.     |
  Fly    92 GTRIGINRVWQGTAPRVLLFEPETVEPILNSQ---KFVNKSHDYDYLHPWLGEGLLTST-----D 148

Human   124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAY------SMD 182
            .:|...|.:|:|.|....|.:.:.:..:...||.|.|  ..|.|     .:.|..:      ::|
  Fly   149 RKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKL--AVEVG-----SEAFNLFPYVTLCTLD 206

Human   183 VITSTSFGVNIDSLNNPQDPFVE------------NTKKLLRFDFLDPFFLSITVFPFLIPILE- 234
            ::..|:.|..|.:.:|.:..:|:            ..|..|:.||:........:....|..|.
  Fly   207 IVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHG 271

Human   235 VLNICVFPREVTNFLRKSVKRMKESRLEDT-----QKHRVDFLQLMIDSQNSKETESHKALSDLE 294
            ..|:.:..|:....:.:.......:...|.     :|.|:.||.|:||:  |||   ...||:.:
  Fly   272 FSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDA--SKE---GTVLSNED 331

Human   295 LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL--PNKAPPTYDTVLQMEYLD 357
            :..:...|:|.|::|||:.:|:.::.|..||:.|:::.||:|::.  ..:.|.|...::.|.||:
  Fly   332 IREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLE 396

Human   358 MVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKK 422
            ..:.::|||||....:.|:..:||.|.|..:|.|...:|.:|||||:|:.:.:||:|.|:.|..:
  Fly   397 CCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPE 461

Human   423 NKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG--LLQP 485
            |.....|:.|.||.:|||||||.:||::..|..:..||:.:..:.....:   .|:|.|  :|:|
  Fly   462 NCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRRE---DLTLLGELILRP 523

Human   486 EKPVVLKVESRD 497
            :..:.:|:..||
  Fly   524 KDGLRVKITPRD 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	128/497 (26%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	128/497 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810