DRSC/TRiP Functional Genomics Resources

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Protein Alignment CYP3A4 and Cyp6a18

DIOPT Version :9

Sequence 1:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens
Sequence 2:NP_001287562.1 Gene:Cyp6a18 / 43304 FlyBaseID:FBgn0039519 Length:507 Species:Drosophila melanogaster


Alignment Length:520 Identity:164/520 - (31%)
Similarity:265/520 - (50%) Gaps:52/520 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    11 TWLL--LAVSLVLLYLYGTHSH-GLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVW 72
            |:.|  :||:|:.:..|..|.. ..||:.|||...|.|..||:..|.|...:.  |.|::|...:
  Fly     4 TYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVH--EIHQEYYNKY 66

Human    73 --------GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKSAISIAEDE 124
                    |||..|:|...:.|.::.|.:|:|. :|.||::..:     .|   |.:.:...:..
  Fly    67 RNSKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIYYNEKDDP---MSAHLFNLDGP 127

Human   125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSF 189
            :|:.|||.||.||||||:|.|.|.:....:..:..:..:......:.::|:...:::|||.:.:|
  Fly   128 QWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAF 192

Human   190 GVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLS--ITVFPFLIPILEVLNICVFPREVTNFLRKS 252
            |:..:||.:.:..|:...::.| .|......:|  :..:|.|   ...|.:|....::..|.::.
  Fly   193 GIKCNSLRDEKAEFLHFGRRAL-LDSRHGNLVSGLMRSYPNL---ARRLGLCRNTAQIQEFYQRI 253

Human   253 VKRMKESRLEDTQKHRVDFLQLMIDSQNSKET-----ESHKALSDLELVAQSIIFIFAGYETTSS 312
            ||.....|.::..| |.||:.::|..:|.|..     |..|.|:..|:|||:.:|..||::|:||
  Fly   254 VKETVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSS 317

Human   313 VLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERV 376
            .:.|.:||||.:|.:|.|::.|:..||...... ||:.:..::|||.|:|||||.:.|...::||
  Fly   318 TMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRV 382

Human   377 CKKDVEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438
            ..|...:.|   ..|..|..|:|||.|:|.||..:.||.:|.|||||.:.........:.|||.|
  Fly   383 AAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEG 447

Human   439 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK--------LSLGGLLQPEKPVVLKVES 495
            ||||||:||..|..::.|..:::||:|.||..|..||.        |.:.|.:|      ||||:
  Fly   448 PRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAILLGIKGGIQ------LKVEA 506

Human   496  495
              Fly   507  506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYP3A4NP_059488.2 p450 39..493 CDD:365848 150/485 (31%)
Cyp6a18NP_001287562.1 p450 38..504 CDD:278495 149/482 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 1 1.000 - - FOG0000037
OrthoInspector 1 1.000 - - mtm8447
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.820

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