DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A4 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	178/533 - (33%)
Similarity:	280/533 - (52%)	Gaps:	68/533 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     9 METWLLLAVSLV-LLYLYGTHSHGLFKKLGIP--GPTPLPF--LGNILSYHK--GFCMFDMECHK 66
            |.:.:||||:|: |.:.|....:..:::.|.|  ..:.:||  |.::....|  |..::|:....
  Fly     1 MFSLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWRQEKSMGLAIYDVYVKS 65

Human    67 KYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYS-------VFTNRRPFGPVGFMKSAISIAEDE 124
            | .:|.|.|...:|.:.|.|.|:.:.||.::..|       |...|.|      :.:.|.....:
  Fly    66 K-ERVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDP------LSANIFSLRGQ 123

Human   125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE-AETG-KPVTLKDVFGAYSMDVITST 187
            .|:.:|.:|||.|||||||.|.......||.:|.:|::| .|.| |.|.:|.|...|::|:|.||
  Fly   124 SWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIAST 188

Human   188 SFGVNIDSLNNPQDPFVENTKKLL-------RFDFLDPFFLSITVFPFLIP-ILEVLNICVFPRE 244
            .||::::|..||.:.|    :||:       ||:.:  |.:.|    ||:| |.:.|....|...
  Fly   189 IFGLDVNSFENPDNKF----RKLVSLARANNRFNAM--FGMMI----FLVPSIAQFLFRIGFKNP 243

Human   245 VTNFLRKSVKRMKESRLEDTQKH---RVDFLQLMIDSQNS--------------KETESH-KALS 291
            |...:.:.||...|.|    :||   |.|.|||:|..:|:              |..:.| |.:|
  Fly   244 VGLAMLQIVKETVEYR----EKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTIS 304

Human   292 DLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEY 355
            ...:.||:.||..||.|||.|..:|.:||||.:|::.::||:|:|..| .|....|||::.:||:
  Fly   305 LEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEF 369

Human   356 LDMVVNETLRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
            ||:.|.||:|.:|....|.|.|.:|..:  ....||||..|:|..|.:|.|.:|:.:||.:.|||
  Fly   370 LDLCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPER 434

Human   419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 483
            ||:::: |.:|..:.|||.|||.||..|...:|.|||:|::||||:.:....::|..:.| |..|
  Fly   435 FSEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFENS-GIAL 497

Human   484 QPEKPVVLKVESR 496
            .|:..|.:::..|
  Fly   498 IPKHGVRVRLSKR 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	168/497 (34%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	160/464 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920